Enzymes in the Synthesis of Block and Graft Copolymers

Howdle, Steven M.; Heise, Andreas

doi:10.1002/9783527632534.ch12

Cited by 1 publication

(2 citation statements)

References 46 publications

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“…The functionalities provide a platform for post‐polymerization derivatization of materials and enable tailoring their mechanical properties, degradability and biocompatibility . Recently, the versatility of lipases has been demonstrated in producing complex macromolecular architectures via chemoenzymatic methods . Here, we highlight the recent advances in the lipase‐catalyzed synthesis of macrolactones and their polymers.…”

Section: Introductionmentioning

confidence: 98%

“…[26][27][28] Recently, the versatility of lipases has been demonstrated in producing complex macromolecular architectures via chemoenzymatic methods. [29] Here, we highlight the recent advances in the lipase-catalyzed synthesis of macrolactones and their polymers. Enzyme-catalyzed macrocyclization is particularly relevant as it can render complete synthetic pathways more sustainable.…”

Section: Introductionmentioning

confidence: 99%

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Recent Developments and Optimization of Lipase-Catalyzed Lactone Formation and Ring-Opening Polymerization

Champagne

Strandman

Zhu

2016

Macromol. Rapid Commun.

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To obtain materials useful for the biomedical field, toxic catalysts should be removed from the synthetic route of polymerization reactions and of their precursors. Lipase-catalyzed ring-opening polymerization and the synthesis of cyclic precursors can be performed with the same catalyst under different conditions. Here, we highlight the use of lipases as catalysts and optimization of their performance for both ring-closing and ring-opening polymerization, via varying parameters such as ring size, concentration, substrate molar ratio, temperature, and solvent. While the conditions for ring-closing reactions and ring-opening polymerizations of small molecules, such as ε-caprolactone, have been extensively explored using Candida antarctica lipase B (CALB), the optimization of macrocyclization, especially for more bulky substrates is surveyed here. Finally, recent methods and polymer architectures are summarized with an emphasis on new procedures for more sustainable chemistry, such as the use of ionic liquids as solvents and recycling of polyesters by enzymatic pathways.

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Section: Introductionmentioning

confidence: 98%