Enzymic and molecular characteristics of a new form of monoamine oxidase, distinct from form-A and form-B.

Yoshino, Morihiko; Obata, Toshio; Sho, Sadayuki; Kinemuchi, Hiroyasu

doi:10.1254/jjp.35.105

Cited by 21 publications

(5 citation statements)

References 34 publications

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“…However, the mechanisms producing such a warm zone during the night have not necessarily been clarified yet. Yoshino (1986) made a comprehensive review of studies on thermal belts and defined the thermal belt as a warm zone on a hillside below which air temperature decreases with decreasing altitude as a result of the formation of a cold-air lake over the foot of a hill; air temperature also decreases with altitude above the zone because of the vertical temperature gradient in the atmosphere. This definition is simple and clear, and seems to be widely accepted.…”

Section: Introductionmentioning

confidence: 99%

An Observational Study of a Thermal Belt on Hillsides

Kobayashi

Mori

Wakimizu

et al. 1994

Journal of the Meteorological Society of Japan

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A thermal belt or a warm zone on a hillside, developing under calm weather conditions during the night, is one of the well-known local climatic phenomena. Although many models describing its fundamental concept have been constructed, very little observational data exists to support the models directly.The difficulty in studying local climatic phenomena lies mainly in collecting data. In the present study, an infrared radiation thermometer installed on the roof of a high building was used to obtain data for analyzing the air temperature structure in complex terrain. The altitude data set (Digital National Land Information, Japan) also was utilized to examine the dependence of air temperature on topography by applying multiple regression analysis.It is confirmed by observation that a thermal belt on a hillside is produced by nocturnal drainage winds and by a cold-air lake which is formed over the basin by the drainage wind and radiative cooling. The height and intensity of a thermal belt are subject to local and temporal variations due to topographical environments and weather conditions, and can vary from hill to hill, even in situations where they are located face to face. These results show that a thermal belt is a phenomenon produced dynamically by the movement of cold air.

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Section: Introductionmentioning

confidence: 99%

An Observational Study of a Thermal Belt on Hillsides

Kobayashi

Mori

Wakimizu

et al. 1994

Journal of the Meteorological Society of Japan

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“…Thus, according to literature data, the enzyme of pacu Piaracus mesopotamicus Holmberg [2], of sheatfish Parasilus asotus [4], of trout Salmo gairdneri [6], and of the common perch Pera flavenscens [16] have the higher sensitivity to chlorgilin than deprenil and the significantly lower than the enzyme of mammals. In the case of carp Cyprinus carpio [5,17], pike Esox lu-YAGODINA, BASOVA cius [18], and zebrafish Danio rerio [7] there is revealed equal sensitivity of the enzyme to chlorgilin and deprenil. The same effect was observed under action of selective reversible inhibitors of MAO A-FLA 788(+), FLA 336(+) (amiflamine) and MAO B-MD 780236 on the brain MAO of carp Cyprinus carpio [5].…”

Section: Resultsmentioning

confidence: 96%

“…In the case of carp Cyprinus carpio [5,17], pike Esox lu-YAGODINA, BASOVA cius [18], and zebrafish Danio rerio [7] there is revealed equal sensitivity of the enzyme to chlorgilin and deprenil. The same effect was observed under action of selective reversible inhibitors of MAO A-FLA 788(+), FLA 336(+) (amiflamine) and MAO B-MD 780236 on the brain MAO of carp Cyprinus carpio [5]. Several selective inhibitors of human MAO B have been shown to inhibit the ZMAO activity [1], whereas selective reversible inhibitors of human MAO B do not inhibit activity of this enzyme.…”

Section: Resultsmentioning

confidence: 96%

Comparative enzymologic study of catalytical properties of liver monoamine oxidases of sturgeon fish

Yagodina

Basova

2013

J Evol Biochem Phys

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We carried out the comparative study of the substrate and inhibitory specificity of liver monoamine oxidases (MAO) of the giant sturgeon Huso huso, the starred sturgeon Acipenser stellatus, the Persian sturgeon Acipenser persicus, and the Russian sturgeon Acipenser gueldenstaedtii. Results of the substrate-inhibitor analysis with use of inhibitors chlorgilin and deprenil, as well as five specific substrates indicate homogeneity of these enzymes. All studied MAO have the several orders higher sensitivity to chlorgilin than to deprenil, with essential interspecies differences being observed. There are determined kinetic parameters of enzymatic deamination (K M and V) of tyramine, serotonin, noradrenalin, benzylamine, β-phenylethylamine, and N-methylhistamine. All studied enzymes have been established to have the higher activity toward serotonin and noradrenalin-substrates of the MAO A form as compared with benzylamine, β-phenylethylamine, and N-methylhistamine-substrate of the mammalian MAO B form, the maximal activity being characteristic of the giant sturgeon. and by predominant oxidation of substrates [1]. MAO, like other membrane-bound enzymes, are difficult to be isolated in a poor state; therefore, the substrate and inhibitor analyses are extremely convenient way of study of catalytical properties of this enzyme. Among the majority of MAO, of particular importance is enzyme of fish organs and tissues owing to an expressed peculiarity of its substrate and inhibitor characteristics. Based on results of the substrate-inhibitor analysis, a suggestion is put forward about the presence in liver and brain of the fish paku Piaractus mesopotamicus Holmberg [2], goldfish Carassius auratus L. [3], and the sheatfish Parasilus asotus [4] of one MAO form similar with the MAO A form of terrestrial mammals, while in liver of carp Cyprinidae [5], the rainbow trout Salmo gairdneri [6], and the zebrafish Danio rerio [7]-about the presence

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“…Previously, we have reported that, fish, common carp (Cyprinus carpio) brain, liver and heart mitochondria contain only a single form of MAO (Kinemuchi et al, 1983a), containing FAD as its possible prosthetic group (Yoshino et al, 1984). Like mammalians MAO (Oreland et al, 1973;Brown et al, 1980;Chen et al, 1994), the molecular mass of the carp brain and liver MAO was found to be about 60 kDa, as estimated by SDS gel electrophoresis after irreversible attachment with the radioactive pargyline (Yoshino et al, 1984;Obata et al, 1990).…”

Section: Introductionmentioning

confidence: 93%

“…Like mammalians MAO (Oreland et al, 1973;Brown et al, 1980;Chen et al, 1994), the molecular mass of the carp brain and liver MAO was found to be about 60 kDa, as estimated by SDS gel electrophoresis after irreversible attachment with the radioactive pargyline (Yoshino et al, 1984;Obata et al, 1990). Carp MAO seems to belong to neither the MAO-A nor to the MAO-B form in mammalian species, since it showed single sigmoidal inhibition curves with identical sensitivities to inhibition by the selective, irreversible MAO-A and MAO-B inhibitors (Kinemuchi et al, 1983a), as well as selective, reversible MAO inhibitors (Yoshino et al, 1984;Arai et al, 1986). These identical and single-sigmoidal inhibition curves of MAO activity by clorgyline and l-deprenyl and time-dependent inhibitor sensitivity was found regardless of whether tyramine, a substrate for both forms of MAO, 5-HT, a preferred MAO-A or β-phenylethylamine, a preferred MAO-B substrate at respectively low concentrations , were used.…”

Section: Introductionmentioning

confidence: 99%