Enzymic and ultrastructural changes in rat liver due to whole body vibration

Ivanovich, E; Antov, G; Kazakova, B

doi:10.1007/bf00409370

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…These include increases in respiratory rate, tidal ventilation, and oxygen consumption (18); increases in cardiac output, pulse pressure, and heart rate (19,20); reductions in systemic vascular resistance (2 1); regional peripheral vasoconstriction (22); reduction in blood eosinophil count and increase in neutrophil count (23); histological renal and hepatic changes (24) and increase in blood SGOT concentration (24); chest and abdominal discomfort and pain (25); and death (26). Despite these reported adverse effects of vibration, HFV has been introduced for clinical practice without a full evaluation of its safety.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Negative Pressure External High Frequency Oscillation on Cerebral Blood Flow and Cardiac Output of the Monkey

et al. 1987

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ABSTRACT. The cerebral and systemic hemodynamic effects of negative pressure ventilation by external high frequency oscillation, utilizing a thoracoabdominal chamber, were investigated in six healthy adult monkeys. Cardiac output and cerebral blood flow were compared on external high frequency oscillation and conventional, positive pressure, mechanical ventilation in each animal. Cardiac output was measured by thermodilution and cerebral blood flow was measured by the intraarterial Xenon'33 clearance technique. Oxygen delivery and consumption and systemic and pulmonary vascular resistances were calculated. There was no significant difference between the two ventilatory modes for any of these variables. Cardiac index on conventional mechanical ventilation was 2.87 2 0.39 1. min-' m-2 (mean f SD) and on external high frequency oscillation was 2.96 f 0.87 1 min-' W2. Cerebral blood flow was 43.9 2 9.1 ml. 100 g-' .min-' on conventional and 39.0 +: 9.0 ml .I00 g-' . min-' on external high frequency ventilation. External high frequency oscillation is not associated with any adverse cardiovascular or cerebrovascular effects and could be introduced for short-term human trials. (5,6). In an effort to take advantage of the mechanisms of gas exchange during HFV, and noting the successful application of HFV to the chest wall of animals (7, 8), we have developed a method of EHFO applied to the abdomen and chest wall which, by use of negative pressure, maintains or improves lung volume (9). EHFO is effective both with and without an endotracheal tube, in cats with normal lungs and in cats with poorly compliant, saline

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Section: Discussionmentioning

confidence: 99%

The Effects of Negative Pressure External High Frequency Oscillation on Cerebral Blood Flow and Cardiac Output of the Monkey

et al. 1987

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“…Vibration has been linked to structural damage in various internal organs and tissues. [3][4][5][6][7][8][9][10] For example, whole body vertical sinusoidal vibration (100 Hz, 2 hours/day for 10 days) resulted in damage to cellular organelles in the liver, including enlarged and elongated mitochondria with reduced cristae, enlarged cisternae in the sarcoplasmic reticulum and large areas of intracellular glycogen. 9 A single 4 hour session of local vibration at 30, 120, or 800 Hz in a rat tail model evoked endothelial and nerve cell disruption (including swollen and disrupted myelin, intraneural edema and dilated arterioles within the ventral tail nerve) and elevated nitrotyrosine immunoreactivity indicative of free-radical damage.…”

Section: Introductionmentioning

confidence: 99%

Responses of the Acutely Injured Spinal Cord to Vibration that Simulates Transport in Helicopters or Mine-Resistant Ambush-Protected Vehicles

Streijger

Lee

Manouchehri

et al. 2016

Journal of Neurotrauma

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In the military environment, injured soldiers undergoing medical evacuation via helicopter or mine-resistant ambush-protected vehicle (MRAP) are subjected to vibration and shock inherent to the transport vehicle. We conducted the present study to assess the consequences of such vibration on the acutely injured spinal cord. We used a porcine model of spinal cord injury (SCI). After a T10 contusion-compression injury, animals were subjected to 1) no vibration (n = 7-8), 2) whole body vibration at frequencies and amplitudes simulating helicopter transport (n = 8), or 3) whole body vibration simulating ground transportation in an MRAP ambulance (n = 7). Hindlimb locomotor function (using Porcine Thoracic Injury Behavior Scale [PTIBS]), Eriochrome Cyanine histochemistry and biochemical analysis of inflammatory and neural damage markers were analyzed. Cerebrospinal fluid (CSF) expression levels for monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-6, IL-8, and glial fibrillary acidic protein (GFAP) were similar between the helicopter or MRAP group and the unvibrated controls. Spared white/gray matter tended to be lower in the MRAP-vibrated animals than in the unvibrated controls, especially rostral to the epicenter. However, spared white/gray matter in the helicopter-vibrated group appeared normal. Although there was a relationship between the extent of sparing and the extent of locomotor recovery, no significant differences were found in PTIBS scores between the groups. In summary, exposures to vibration in the context of ground (MRAP) or aeromedical (helicopter) transportation did not significantly impair functional outcome in our large animal model of SCI. However, MRAP vibration was associated with increased tissue damage around the injury site, warranting caution around exposure to vehicle vibration acutely after SCI.

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Occupational liver injury

Døssing

Skinhøj

1985

Int Arch Occup Environ Health

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Epidemiological studies have mapped the occurrence of hepatitis B among health personnel with the use of specific serologic markers and thereby made rational preventive precautions possible. Follow-up studies have demonstrated the effect of this prevention, and the newly developed hepatitis B vaccine has further improved the possibilities for effective prophylaxis against occupational hepatitis B. On the other hand, there is the chemically induced occupational liver damage. Only a few of the thousands of industrially used chemicals have been sufficiently investigated for hepatotoxicity and the list of suspected and confirmed hepatotoxic agents is still growing. The worrisome example of vinylchloride-induced serious liver disease among PVC-workers, revealed after 42 years of industrial use by alert clinicians, calls for intensified activities in the field of occupational hepatotoxicity. However, the clinical, biochemical, and morphological features of liver disease are often vague and unspecific. A non-invasive, convenient quantitative liver function test is needed. Circumstantial evidence and a few epidemiological studies suggest that part of the so-called cryptogenic liver diseases, such as liver cirrhosis, may be caused by occupational exposure to chemicals. This should be further studies. Animal experiments have shown that one chemical agent may potentiate the hepatotoxic effect of another chemical agent. This should be the subject of investigations in the work environment, where exposure to various chemicals is the rule rather than the exception. Alcohol consumption may also interfere with the hepatotoxicity of occupationally used chemicals.

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Enzymic and ultrastructural changes in rat liver due to whole body vibration

Cited by 3 publications

References 6 publications

The Effects of Negative Pressure External High Frequency Oscillation on Cerebral Blood Flow and Cardiac Output of the Monkey

The Effects of Negative Pressure External High Frequency Oscillation on Cerebral Blood Flow and Cardiac Output of the Monkey

Responses of the Acutely Injured Spinal Cord to Vibration that Simulates Transport in Helicopters or Mine-Resistant Ambush-Protected Vehicles

Occupational liver injury

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