Enzymology and significance of protein histidine methylation

Abstract

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Covalent Chemical Tools for Profiling Post-Translational Modifications

“…Arginine can be methylated once (monomethylated arginine) or twice, either with both methyl groups on one terminal nitrogen (asymmetric dimethylarginine) or one on both nitrogen’s (symmetric dimethylarginine), by enzyme arginine methyltransferases (PRMTs) ( Yang and Bedford, 2013 ). Histidine can be methylated at two different positions either 1st or 3 rd position and recently has been shown to play important role in biological processes ( Jakobsson, 2021 ) ( Figure 6A ).…”

Probing lysine posttranslational modifications by unnatural amino acids

“…Two enzymes, SETD3 and METTL18 catalyse N τ -methylation of histidine, while CARNMT1 and METTL9 catalyse N π -methylation of histidine. 139,140 SETD3 was recently identified as the enzyme solely responsible for the methylation of histidine at position 73 in β-actin and is biomedically relevant, making it a particularly interesting target for molecular investigations. 141 SETD3 was found to catalyse methylation of structurally and chemically diverse histidine mimics in β-actin peptides.…”

Elevated METTL9 is associated with peritoneal dissemination in human scirrhous gastric cancers

“…Chemical modifications of DNA, RNA, and proteins substantially affect the stability, activity, and functions of cell components [ 5 ]. In particular, methylation on cellular components mediated by over 200 enzymes, is attentive topic for post-transcriptional and post-translational regulation [ 6 ]. Furthermore, the aberrant regulation of chemical modification leads to the onset of diverse diseases, including cancers [ 7 ].…”