Enzymology of Gout

Kelley, William N.; Wyngaarden, James Β.

doi:10.1002/9780470122860.ch1

Cited by 4 publications

(2 citation statements)

References 125 publications

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“…Xanthine oxidase relates to purine metabolism and converts xanthine or hypoxanthine into uric acid. It has been reported that the increase in uric acid and an accumulation in the blood and bones result in gout, and an accumulation in the kidney occasionally induces kidney trouble 40–42 . The xanthine oxidase inhibition effect is important biologically for the inhibition of free radical production.…”

Section: Resultsmentioning

confidence: 99%

“…It has been reported that the increase in uric acid and an accumulation in the blood and bones result in gout, and an accumulation in the kidney occasionally induces kidney trouble. [40][41][42] The xanthine oxidase inhibition effect is important biologically for the inhibition of free radical production. Many studies have been conducted on this objective using various natural materials.…”

Section: Xanthine Oxidase Inhibition Effectmentioning

confidence: 99%

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Inhibition of Enzyme Activities and the Antiwrinkle Effect of Polyphenol Isolated from the Persimmon Leaf (Diospyros kaki folium) on Human Skin

An¹,

Kwak²,

Park³

et al. 2005

Dermatologic Surgery

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Section: Resultsmentioning

confidence: 99%

Section: Xanthine Oxidase Inhibition Effectmentioning

confidence: 99%

Inhibition of Enzyme Activities and the Antiwrinkle Effect of Polyphenol Isolated from the Persimmon Leaf (Diospyros kaki folium) on Human Skin

An¹,

Kwak²,

Park³

et al. 2005

Dermatologic Surgery

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Tryptic peptide analysis of normal and mutant forms of hypoxanthine phosphoribosyltransferase from HeLa cells.

Milman¹,

Krauss²,

Olsen³

1977

Proc. Natl. Acad. Sci. U.S.A.

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Hypoxanthine phosphoribosyltransferase (HPRT, atmosphere of 5% C02/95% air. Methods for growing cells on plastic petri plates and for the selection of HPRT-deficient mutants or revertants have been previously described (12). When large quantities of cells are desired, they are grown in suspension at a density of S to 100 X 104/ml in Joklik's modified minimal essential medium (Gibco, 13.3 g of powder medium per liter) containing 5% calf serum (Irvine Scientific).Radioisotope-labeled amino acids are incorporated into HeLa proteins as previously described (12) buffer (10 mM MgCl2, 30 mM KC1, 0.1 mM dithiothreitol, 0.5% Triton X-100, and 10 mM Tris-HCl, pH 7.4) and centrifuged for 2 hr at 96,000 X g in a Spinco type 50 rotor. The high-speed supernatant fraction is removed, and to 2 ml supernatant are added 0.6 ml enzyme buffer (20 mM KC1, 6 mM MgCl2, 0.1 mM EDTA, 0.5 mM dithiothreitol, and 20 mM Tris-HCl, pH 7.8), 0.4 ml of a solution containing 10% Triton X-10(0 by volume and 10% sodium deoxycholate by weight, and 1.0 ml of 4 M NaCI. The sample is applied to 0.12 ml of

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Tomographic, Biomechanical, and In Vivo Confocal Microscopic Changes in Cornea in Chronic Gout Disease

Icoz,

Yildiz Tasci,

Erten

et al. 2024

Ocular Immunology and Inflammation

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Enzymology of Gout

Cited by 4 publications

References 125 publications

Inhibition of Enzyme Activities and the Antiwrinkle Effect of Polyphenol Isolated from the Persimmon Leaf (Diospyros kaki folium) on Human Skin

Inhibition of Enzyme Activities and the Antiwrinkle Effect of Polyphenol Isolated from the Persimmon Leaf (Diospyros kaki folium) on Human Skin

Tryptic peptide analysis of normal and mutant forms of hypoxanthine phosphoribosyltransferase from HeLa cells.

Tomographic, Biomechanical, and In Vivo Confocal Microscopic Changes in Cornea in Chronic Gout Disease

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