Polymer flooding is an enhanced oil recovery (EOR) method used to increase oil recovery from oil reservoirs beyond primary and secondary recovery. Although it is one of the most well-established methods of EOR, there are still continuous new developments and evaluations for this method. This is mainly attributed to the diverse polymers used, expansion of this method in terms of application, and the increase in knowledge pertaining to the topic due to the increase in laboratory testing and field applications. In this research, we perform a review of the factors impacting polymer flooding in both laboratory studies and field-based applications in order to create guidelines with respect to the parameters that should be included when designing a polymer flooding study or application. The main mechanism of polymer flooding is initially discussed, along with the types of polymers that can be used in polymer flooding. We then discuss the most prominent parameters that should be included when designing a polymer flooding project and, based on previous laboratory studies and field projects, discuss how these parameters impact the polymer itself and the flooding process. This research can provide guidelines for researchers and engineers for future polymer flooding research or field applications.