Eosinophil activation and novel mediators in the aspirin‐induced nasal response in <scp>AERD</scp>

Choi, Gil Soon; Kim, J.-H.; Shin, Yoo Seob; Ye, Y.-M.; Kim, S.-H.; Park, Hae‐Sim

doi:10.1111/cea.12096

Cited by 32 publications

(23 citation statements)

References 52 publications

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“…AERD patients exhibit increased levels of inflammatory mediators including CysLTs, ECP, IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), eotaxin, and regulated on activation, normal T cell expressed and secreted (RANTES); all are produced predominantly by eosinophils [3,9,18]. Steinke et al [19 && ] recently showed that higher INF-g levels produced…”

Section: Inflammatory Cells and Cytokinesmentioning

confidence: 99%

Upper airways in aspirin-exacerbated respiratory disease

Choi

Kim

Park

2015

Current Opinion in Allergy &Amp; Clinical Immunology

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Section: Inflammatory Cells and Cytokinesmentioning

confidence: 99%

Upper airways in aspirin-exacerbated respiratory disease

Choi

Kim

Park

2015

Current Opinion in Allergy &Amp; Clinical Immunology

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“…It has been shown in AERD that CysLTs release reaches their maximal values in the nasal lavage 30 minutes after lysine-aspirin instillation, in parallel with the rise in eosinophil cationic protein (ECP). Symptoms of sneezing, nasal congestion and rhinorrhea appear much faster as the total nasal symptom score is already elevated after 10 minutes 18. In another study, increases in tryptase and PGD 2 are also observed, whereas PGE 2 decreasesas ECP increases 19…”

Section: Clinical Studies On Eicosanoids In Asthmamentioning

confidence: 88%

Eicosanoid Mediators in the Airway Inflammation of Asthmatic Patients: What is New?

Sanak

2016

Allergy Asthma Immunol Res

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Lipid mediators contribute to inflammation providing both pro-inflammatory signals and terminating the inflammatory process by activation of macrophages. Among the most significant biologically lipid mediators, these are produced by free-radical or enzymatic oxygenation of arachidonic acid named "eicosanoids". There were some novel eicosanoids identified within the last decade, and many of them are measurable in clinical samples by affordable chromatography-mass spectrometry equipment or sensitive immunoassays. In this review, we present some recent advances in understanding of the signaling by eicosanoid mediators during asthmatic airway inflammation. Eicosanoid profiling in the exhaled breath condensate, induced sputum, or their metabolites measurements in urine is complementary to the cellular phenotyping of asthmatic inflammation. Special attention is paid to aspirin-exacerbated respiratory disease, a phenotype of asthma manifested by the most profound changes in the profile of eicosanoids produced. A hallmark of this type of asthma with hypersensitivity to non-steroid anti-inflammatory drugs (NSAIDs) is to increase biosynthesis of cysteinyl leukotrienes on the systemic level. It depends on transcellular biosynthesis of leukotriene C4 by platelets that adhere to granulocytes releasing leukotriene A4. However, other abnormalities are also reported in this type of asthma as a resistance to anti-inflammatory activity of prostaglandin E2 or a robust eosinophil interferon-γ response resulting in cysteinyl leukotrienes production. A novel mechanism is also discussed in which an isoprostane structurally related to prostaglandin E2 is released into exhaled breath condensate during a provoked asthmatic attack. However, it is concluded that any single eicosanoid or even their complex profile can hardly provide a thorough explanation for the mechanism of asthmatic inflammation.

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“…IL-8 in the respiratory tract might conceivably activate eosinophils, thus participating in local immune modulation via degranulation. Eosinophil activation is important in upper and lower respiratory inflammation,47 and IL-8 is important for eosinophil attraction and function 48. Exercise-induced recruitment and degranulation of eosinophils and basophils to the respiratory tract due to airway inflammation might explain the exercise-induced URTS increase seen in this study and others.…”

Section: Discussionmentioning

confidence: 99%

Is baseline aerobic fitness associated with illness and attrition rate in military training?

2016

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Respiratory illnesses are a leading cause of morbidity and medical discharge in the military. This study aimed to investigate the effects of baseline aerobic fitness on haematological, salivary and mood variables, and simultaneously, in a novel approach, to identify factors precipitating illness and attrition rate in recruits during military training.Thirty-five healthy male recruits from an Army Training Regiment undertaking 12 weeks of training were prospectively investigated. Their 2.4 km run time (RT) was used as a surrogate of baseline aerobic fitness.Saliva and venous blood samples were analysed for secretory IgA, full blood counts and cell cytokine production (interleukin (IL) 6 and IL-8), respectively. Each recruit completed questionnaires on mood profile, and gastrointestinal and upper respiratory tract symptoms (URTS).Significant salivary and haematological perturbations were observed and coincided with increased duration of URTS/week and mood disturbance over this military training period. From Start to End: leucocyte count decreased by 28% (p<0.001); neutrophil percentage (%) decreased by 13% (p<0.01); lymphocyte % increased by 17% (p<0.05); the neutrophil:lymphocyte ratio decreased by 22% (p<0.01); eosinophil% increased by 71% (p<0.01). From Start to Mid to End: monocyte% increased by 68% at Mid (p<0.01) but only by 30% at End (p<0.01); IL-6 increased by 39% at Mid (p<0.01) and a further 61% by End. The 2.4 km RT was significantly associated with URTS duration (p<0.01). In addition, a 1-min increase in 2.4 km RT increased a recruit's risk 9.8-fold of developing URTS lasting, on average, 3.36 days/week. In recruits ranked with high-URTS duration their RT was 48 s slower (p<0.01) than those with low-URTS, and their attrition rate reached 45%.The least fit recruits may have found training more physically demanding as reflected in the higher URTS duration, which may have led to a high attrition rate from the Army. It is worth considering that baseline aerobic fitness might be an important factor in illness development and attrition rate in recruits during this type of military training.

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Eosinophil activation and novel mediators in the aspirin‐induced nasal response in AERD

Abstract: Eosinophil activation occurred in early and late responses after L-ASA NPT in upper airway mucosa of AERD patients, where ApoA1, α2M and CP as well as CysLT may be involved in eosinophilic inflammation.

Cited by 32 publications

References 52 publications

Upper airways in aspirin-exacerbated respiratory disease

Upper airways in aspirin-exacerbated respiratory disease

Eicosanoid Mediators in the Airway Inflammation of Asthmatic Patients: What is New?

Is baseline aerobic fitness associated with illness and attrition rate in military training?

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