Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke

Sundström, Johannes; Söderholm, Martin; Borné, Yan; Nilsson, Jan; Persson, Margaretha; Östling, Gerd; Melander, Olle; Orho‐Melander, Marju; Engström, Gunnar

doi:10.1161/strokeaha.117.018450

Cited by 20 publications

(22 citation statements)

References 38 publications

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“…17,18 Elevated plasma concentrations of ECP have been associated with increased incidence of ischemic stroke. 19 In patients with systemic lupus erythematosus and lupus nephritis, urine ECP/UCr ratio has been found to have better correlation with renal function and SLE disease activity, compared to urine interleukin-5 (IL-5/UCr ratio). 20 In the current study, we observed that urine ECP/UCr was significantly associated with blood eosinophil counts, systemic inflammation, glomerular lesions, and the average number of cortex infiltrated eosinophils.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that ECP can be used as a marker for estimating eosinophil inflammatory activity in asthma and other inflammatory diseases, and its levels are related to disease severity 17,18 . Elevated plasma concentrations of ECP have been associated with increased incidence of ischemic stroke 19 . In patients with systemic lupus erythematosus and lupus nephritis, urine ECP/UCr ratio has been found to have better correlation with renal function and SLE disease activity, compared to urine interleukin‐5 (IL‐5/UCr ratio) 20 .…”

Section: Discussionmentioning

confidence: 99%

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Interstitial eosinophilic infiltration in diabetic nephropathy is indicative of poor prognosis, with no therapy benefit from steroid

Zhou

Sun

et al. 2020

Journal of Diabetes

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Background: Studies suggested that eosinophils in diabetes might be associated with severity of diabetic nephropathy (DN). In a retrospective study of 102 Chinese patients with biopsy-proven DN, we aimed to evaluate relationships of both blood and renal eosinophils (Eos) to the severity of DN and check whether Eos can serve as an indicator of prognosis as well as the therapeutic effect of steroids. Methods: One hundred and two patients diagnosed with DN were enrolled. Demographical and clinical data and histopathological scores were associated. Interstitial eosinophilic aggregates (IEA) were defined as the presence of ≥10 Eos in at least one high-power field. End-stage renal disease was defined as the end point. Results: We observed that log 2 (blood eosinophil counts) correlated with neutrophil counts, proteinuria, and tubulointerstitial inflammatory cell infiltration. IEA was observed in 33.3% of the DN patients and was associated with decreased estimated glomerular filtration rate, higher proteinuria, hematuria, higher HbA1c, increased blood eosinophil counts, tubular injury, tubulointerstitial chronicity, and interstitial inflammation. IEA was associated with worse renal prognosis (hazard ratio [HR] 2.424, P = 0.008). Consistently, urine eosinophil cationic protein (ECP) (ng/mgCr) was associated with renal injury and poor renal prognosis (HR 1.173, P = 0.020). Patients with IEA were more likely to be treated with steroid/immunosuppressants (47.1% vs 14.7%, P = 0.001) but did not show renal benefit.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interstitial eosinophilic infiltration in diabetic nephropathy is indicative of poor prognosis, with no therapy benefit from steroid

Zhou

Sun

et al. 2020

Journal of Diabetes

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“…Eosinophil granule proteins, including eosinophil cationic protein, eosinophil peroxidase, and major basic protein can cause cytotoxic protein-mediated thrombosis and endothelial injury 30 . ECP also stimulates broblast migration and brosis, which could be play an important role in the development of atherosclerosis [31][32][33][34] . It could be speculated that increased ECP and activated eosinophils were associated with increased incidence of AIS through effects on unstable plaque.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Change of Eosinophil and Acute Ischemic Stroke

Zhao

Feng

et al. 2020

Preprint

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Abstract Background: Eosinopenia has been shown to be a predicative factor for the infection and mortality in ischemic stroke patients which mainly focused on static eosinophil count. This study aimed to explore the relationship between dynamic change of eosinophil count and short-term prognosis of acute ischemic stroke (AIS).Methods: A total of 174 patients with AIS were respectively enrolled. Blood samples for blood routine examination were obtained at admission before any treatments and the next day. Eosinopenia was defined as the continuous decrease of the count of eosinophil from the first day to the second. Infarct volume was measured by diffusion-weighted MR imaging volume. 90-day modified Rankin Scale scores were collected to assess the prognosis of patients with AIS.Results: Patients were divided into two groups according to whether they have eosinopenia. Patients with eosinopenia were more likely to have large infarct volume (3.2 [0.6-39.9] cm3 vs 1.1 [0.3-6.0] cm3, P =.004). Receiver operating characteristic analysis demonstrated that the eosinophil count on the second day was more accurate than the time of admission to identify the large cerebral infarction (LCI) (0.866 vs 0.603, P ＜.001). Logistic regression analysis revealed that eosinopenia was independently associated with LCI (P =.015) and poor outcome (P =.011), and patients with eosinopenia had a 4.05-fold greater risk for LCL (95% CI 1.31-12.51) and a 4.29-fold greater risk for worse clinical outcomes (95% CI 1.27-14.51) than patients without.Conclusion： Eosinophil is a dynamic variable, and its variation is associated with poor outcome in acute ischemic stroke patients.

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“…And, 3-activated eosinophils have prothrombotic functions. 7 Eosinophils is many-sided leukocytes that contributes to many pathological and physiological processes related to CVD risk. The contribution of eosinophils in CVD risk depend on the activation status and on the location of the eosinophils.…”

Section: Reply From the Authormentioning

confidence: 99%

Comment on: Variables associated subclinical atherosclerosis among rheumatoid arthritis patients of Gulf Cooperative Council countries

Jawad

2020

SMJ

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Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke

Abstract: High ECP is associated with increased incidence of IS. The association between ECP and IS was also present in the subgroup with carotid plaque.

Cited by 20 publications

References 38 publications

Interstitial eosinophilic infiltration in diabetic nephropathy is indicative of poor prognosis, with no therapy benefit from steroid

Interstitial eosinophilic infiltration in diabetic nephropathy is indicative of poor prognosis, with no therapy benefit from steroid

Dynamic Change of Eosinophil and Acute Ischemic Stroke

Comment on: Variables associated subclinical atherosclerosis among rheumatoid arthritis patients of Gulf Cooperative Council countries

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