Eosinophil Count Is Positively Correlated with Albumin Excretion Rate in Men with Type 2 Diabetes

Fukui, Michiaki; Tanaka, Muhei; Hamaguchi, Masahide; Senmaru, Takafumi; Sakabe, Kazumi; Shiraishi, Emi; Harusato, Ichiko; Yamazaki, Masahiro; Hasegawa, Goji; Nakamura, Naoto

doi:10.2215/cjn.03330509

Cited by 34 publications

(32 citation statements)

References 20 publications

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“…IL-5 is a T H 2 homodimeric cytokine involved in the differentiation, maturation, migration, development, survival, trafficking and effector function of blood and local tissue eosinophils, in addition to basophils and mast cells [35]. A recent study reported a potential link between IL-5 actions and diabetic nephropathy, since eosinophil count was positively correlated with albumin excretion rate in men with T2D [36]. Moreover, an 8-year prospective cohort analysis of 1327 Chinese patients with T2D reported that polymorphisms in the IL-5 receptor α subunit correlated with ischemic stroke [37].…”

Section: Discussionmentioning

confidence: 99%

Cytokine profiling of young overweight and obese female African American adults with prediabetes

et al. 2013

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Approximately 5–10% of subjects with prediabetes become diabetic every year. Inflammation is involved in the development of obesity-related type 2 diabetes (T2D). However, to date, the relationship between inflammation and prediabetes, defined by hemoglobin A1c (HbA1c) ≥ 5.7 and < 6.5%, remains largely unexplored, especially in African Americans. Therefore, in this study we examined a comprehensive panel of 13 cytokines involved in the inflammatory response in overweight/obese subjects with prediabetes. A total of 21 otherwise healthy, overweight/obese, young adult African American females with prediabetes, together with 20 matched overweight/obese controls, were selected for this study. Plasma cytokines were assessed by multiplex cytokine profiling. Plasma concentrations of interleukin (IL)-5, IL-6, IL-7, tumor necrosis factor-α (TNF-α), and granulocyte-monocyte colony-stimulating factor (GM-CSF) were significantly higher in the prediabetic group, as compared to the control group (all p < 0.05). Plasma concentrations of all the other cytokines, interferon-γ (IFN-γ), IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12p70 and IL-13, seemed to be elevated in the prediabetic group, but failed to reach statistical significances. Upon merging both groups, HbA1c was found to be positively correlated with IFN- γ, IL-1β, IL-2, IL-5, IL-7, IL-8, TNF-α and GM-CSF. This study demonstrates elevated levels of various pro-inflammatory cytokines in overweight/obese young subjects with prediabetes, which place them at higher risk of developing T2D and cardiovascular diseases. Our data also call for further investigations in animal models and population cohorts to establish the roles of a variety of pro-inflammatory cytokines in the early development of obesity-related T2D.

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Section: Discussionmentioning

confidence: 99%

Cytokine profiling of young overweight and obese female African American adults with prediabetes

et al. 2013

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“…Defining the regulation of inflammatory pathways and metabolic signals is a complex problem to undertake, yet individual findings in clinical studies 58 and use of animal models 59 have suggested a potential role for eosinophils in maintaining metabolic homeostasis. In particular, studies in mice have highlighted a role for eosinophils 59 in modulating adipocyte tissue macrophages, which are important in metabolic homeostasis.…”

Section: Metabolic Syndrome: Adipose Insulin and Inflammationmentioning

confidence: 99%

The expanding role(s) of eosinophils in health and disease

Jacobsen¹,

Helmers

Lee³

et al. 2012

Blood

181

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Surprisingly, the role(s) of eosinophils in health and disease is often summarized by clinicians and basic research scientists as a pervasive consensus opinion first learned in medical/graduate school. Eosinophils are rare white blood cells whose activities are primarily destructive and are only relevant in parasitic infections and asthma. However, is this consensus correct? This review argues that the wealth of available studies investigating the role(s) of eosinophils in both health and disease demonstrates that the activities of these granulocytes are far more expansive and complex than previously appreciated. In turn, this greater understanding has led to the realization that eosinophils have significant contributory roles in a wide range of diseases. Furthermore, published studies even implicate eosinophil-mediated activities in otherwise healthy persons. We suggest that the collective reports in the literature showing a role for eosinophils in an everincreasing number of novel settings highlight the true complexity and importance of this granulocyte. Indeed, discussions of eosinophils are no longer simple and more often than not now begin with the question/statement "Did you know . . .?" (Blood. 2012;120(19):3882-3890)

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“…Eosinophils are potent effector cells in the pathogenesis of many disorders, ranging from allergy and bronchial asthma 1, to eosinophilic esophagitis 2, colitis ulcerosa 3, hypereosinophilic syndrome 4, and renal disease 5. Activated eosinophils are one of the primary sources of cytotoxic proteins, proinflammatory cytokines, and growth factors, such as IL‐4, IL‐5, IL‐10, and IL‐13 6, and promote numerous immunoregulatory functions that lead to the progression of inflammation, mucus secretion, tissue remodeling, and angiogenesis 7.…”

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confidence: 99%

Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen‐induced pulmonary inflammation in mice

Frei

Luschnig

Parzmair

et al. 2016

Allergy

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BackgroundAccumulation of activated eosinophils in tissue is a hallmark of allergic inflammation. The endocannabinoid 2‐arachidonoylglycerol (2‐AG) has been proposed to elicit eosinophil migration in a CB 2 receptor/Gi/o‐dependent manner. However, it has been claimed recently that this process may also involve other mechanisms such as cytokine priming and the metabolism of 2‐AG into eicosanoids. Here, we explored the direct contribution of specific CB 2 receptor activation to human and mouse eosinophil effector function in vitro and in vivo.Methods In vitro studies including CB 2 expression, adhesion and migratory responsiveness, respiratory burst, degranulation, and calcium mobilization were conducted in human peripheral blood eosinophils and mouse bone marrow‐derived eosinophils. Allergic airway inflammation was assessed in mouse models of acute OVA‐induced asthma and directed eosinophil migration.Results CB 2 expression was significantly higher in eosinophils from symptomatic allergic donors. The selective CB 2 receptor agonist JWH‐133 induced a moderate migratory response in eosinophils. However, short‐term exposure to JWH‐133 potently enhanced chemoattractant‐induced eosinophil shape change, chemotaxis, CD11b surface expression, and adhesion as well as production of reactive oxygen species. Receptor specificity of the observed effects was confirmed in eosinophils from CB 2 knockout mice and by using the selective CB 2 antagonist SR144528. Of note, systemic application of JWH‐133 clearly primed eosinophil‐directed migration in vivo and aggravated both AHR and eosinophil influx into the airways in a CB 2‐specific manner. This effect was completely absent in eosinophil‐deficient ∆dblGATA mice.ConclusionOur data indicate that CB 2 may directly contribute to the pathogenesis of eosinophil‐driven diseases. Moreover, we provide new insights into the molecular mechanisms underlying the CB 2‐mediated priming of eosinophils. Hence, antagonism of CB 2 receptors may represent a novel pharmacological approach for the treatment of allergic inflammation and other eosinophilic disorders.

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Eosinophil Count Is Positively Correlated with Albumin Excretion Rate in Men with Type 2 Diabetes

Cited by 34 publications

References 20 publications

Cytokine profiling of young overweight and obese female African American adults with prediabetes

Cytokine profiling of young overweight and obese female African American adults with prediabetes

The expanding role(s) of eosinophils in health and disease

Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen‐induced pulmonary inflammation in mice

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