Eosinophil count is related with coronary thrombus in non ST-elevated acute coronary syndrome

Abstract

Background. White blood cells are reported as important not only in plaque vulnerability but also in thrombus formation and thrombus growth in acute coronary syndromes. Eosinophils contain granules that promote thrombus formation and thrombus growth in some heart diseases. In this study we aimed to investigate the relation of eosinophil count with coronary thrombus formation in patients with non ST-elevated acute coronary syndrome (NST-ACS). Method. A total of 251 consecutive patients were hospitalized in our hospital with a diagnosis of NST-ACS. Venous blood is collected for measurement of hematologic indices in all patients undergoing the coronary angiography. Coronary angiographies were performed in our clinic using the standard Judkins technique and angiographic assessment of the presence of thrombus was made. Results. During coronary angiography, coronary thrombus was not detected in 82 patients (Group 1). In the coronary angiography of 169 patients, coronary thrombus was detected at various grades (Group 2). While the neutrophil count (6.84±1.94 vs. 5.53±1.37; P<0.001) and eosinophil count (0.257±0.125 vs. 0.163±0.114; P<0.005) was significnatly increased in the group with coronary thrombus, the lymphocyte count (1.87±0.66 vs. 2.00±0.70; P<0.001) was significantly decreased in the group with coronary thrombus as compared to the patient group without coronary thrombus. In the correlation analyzes; presence of coronary thrombus is correlated with total cholesterol, LDL-C, total CK, CK-MB, troponin, total number of diseased coronary, platelet count, neutrophil count, lymphocyte count and eosinophil count. On multivariate linear regression analysis, total leukocyte count, neutrophil count, lymphocyte count, eosinophil count, troponin and total cholesterol was found to be independent predictor of coronary thrombus in patients with NST-ACS. Conclusion. Beside the increased neutrophil count, increased eosinophil count in CBC should alert the clinician about coronary thrombus development in patients with NST-ACS in order to make early medical interventions at acute phase of the disease.

Hematological parameters and early-onset coronary artery disease: a retrospective case–control study based on 3366 participants

“…Several studies have demonstrated that an elevated eosinophil count associated with CAD, thereby depicting higher cardiovascular mortality. 37 , 38 However, other studies have reported that CAD patients exhibited lower eosinophil percentages than controls without CAD. 39 Our data indicated that the eosinophil count and percentage were significantly reduced in EOCAD patients and were independent factors influencing disease occurrence.…”

Arterial and venous thromboembolism risk associated with blood eosinophils: A systematic review and meta‐analysis

“…However, Verdoia et al 11 did not find an association between an increased EOS count and NSTEMI in the CAD population (OR: 1.04, 95% CI: 0.86–1.26, p = 0.69) (Figure 2A). In the study by Tenekecioglua et al, 10 an increased EOS count was found to be an independent predictor of coronary thrombus in patients with non‐ST segment elevation acute coronary syndrome (NST‐ACS). However, this study was not included in the pooled analysis because of the converted data.…”

“…Ultimately, 22 articles were included with 805 329 subjects. Of these 22 articles, 13 were cohort studies, 3–9,12,13,20–23 6 were cross‐sectional studies, 10,14,24–27 and 3 were case–control studies 11,28,29 . Of the included studies, 14 studies were related to cardiovascular diseases, 3 were related to cerebral thrombosis/cerebral infarction, and 6 were related to venous thrombotic events, among which the study by Anoop et al involved both cardiovascular disease and cerebral artery thrombosis 9 …”

“…Coronary artery thrombosis and cerebral artery thrombosis, also called acute myocardial infarction (AMI) and ischemic stroke, respectively, are the most common arterial thrombotic diseases affecting patient health. [4][5][6][7][8][9][10][11] Recently, there has been increased clinical interest in the use of EOS counts as a predictor of coronary and cerebral arterial thrombosis disorders. However, the findings concerning EOS count and coronary or cerebral thrombosis disorders vary widely across studies.…”

Comparison of eosinophil counts in patients with acute pulmonary embolism: Could it be a predictor factor

“…It remains unclear how eosinophils are involved in the pathogenesis of thrombus formation. Neurotoxins, eosinophil cationic proteins, and major basic proteins released from eosinophils can cause endothelial damage resulting in fibrosis, thrombosis, and infarction [12]. Also, the enzyme peroxidase and the major basic protein released from eosinophilic granules may lead to thrombus formation by directly activating platelets and inhibiting thrombomodulin [13].…”