Eosinophil counts and urinary eosinophil protein X in children hospitalized for wheezing during the first year of life: prediction of recurrent wheezing

Øymar, Knut; Havnen, J; Halvorsen, Thomas; Bjerknes, Robert

doi:10.1111/j.1651-2227.2001.tb02443.x

Cited by 24 publications

(39 citation statements)

References 28 publications

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“…Boesen addresses the question of whether or not asthmatic bronchitis is a forerunner of bronchial asthma. As emphasized by Korppi and Kotaniemi-Syrjänen, the results presented by Boesen in 1953 are remarkably consistent with their own results from Kuopio, Finland, five decades later (3), and also with results from Sweden and Norway (4)(5)(6).…”

supporting

confidence: 74%

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Outcome of wheezing in early childhood

Wennergren¹

2003

Acta Paediatrica

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Young children admitted to hospital because of wheezing have a clearly increased risk of subsequent asthma. Recent studies confirm Boesen's observations of the prognostic importance of eosinophilia and an inverse relation between age at admission with wheezing and risk of subsequent asthma. Allergy or atopic dermatitis is predictive of subsequent asthma, whereas family history of allergy has low predictive value in infants.

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supporting

confidence: 74%

“…Interestingly, Boesen points out that eosinophilia (!0.4 Â 10 9 L À1 ) was of prognostic importance (2). In recent years, the prognostic value of eosinophilia has been reported in several studies (3,6,11,12). In fact, there are studies indicating that eosinopenia may be considered to be the normal immune response to early viral infections (11,13).…”

mentioning

confidence: 97%

Outcome of wheezing in early childhood

Wennergren¹

2003

Acta Paediatrica

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“…During acute viral respiratory infection, eosinopenia has been considered as a normal response [155,156], and in children with wheezing lower respiratory tract infection, blood eosinophilia or normal eosinophil counts have been predictive of persistent wheezing or asthma [142,145,[156][157][158]. In children hospitalized for wheezing, eosinophilia has been particularly associated with rhinovirus infection [51,159].…”

Section: Role Of Eosinophil Activationmentioning

confidence: 99%

Respiratory Viruses, Eosinophil Activation, and Early Allergen Sensitization - Early Life Predictors of Persistent Wheezing and Asthma

Kotaniemi‐Syrjänen¹,

Korppi

2007

CPR

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Approximately 20% of all children will suffer from wheezing illnesses, and in 1-3% of all infants, respiratory distress is severe enough to require hospitalization. As wheezing infants form a heterogeneous group with different phenotypes and outcomes, it is still a challenge to identify those who will go on wheezing to develop asthma. In order to facilitate the prediction of later asthma, algorithms have been developed for clinical use. The algorithms validated this far are based on personal atopic findings and the parental history of asthma, and blood eosinophilia has been the only laboratory marker included. In this review, we will focus on the role of respiratory viruses, eosinophil activation markers, specific immunoglobulin E antibodies, and skin prick tests, as early life predictors of persistent wheezing and asthma.According to recently published results, rhinoviral infection seems to carry a high risk for persistence of wheezing. Sensitization to inhalant allergens in infancy strongly increases the risk for later respiratory allergy. Eosinophil activation markers seem not to offer significant additional value over blood eosinophils.Determination of viral etiology of wheeze, and/or screening for early sensitization to inhalant allergens in individuals with no clinically evident atopy might be of use in identifying future asthmatics.

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“…However, u-EPX does not seem to predict persistence of wheezing or asthma [69][70][71]. Furthermore, most studies showed a large overlap in u-EPX values between symptomatic and asymptomatic children [68,[70][71][72]. There is some evidence that u-LTE 4 levels are associated with polymorphisms in the cysteinyl leukotrienes pathway genes that are in turn related to treatment responses to montelukast in preschool wheezers [73].…”

Section: Urine Analysismentioning

confidence: 99%

Biomarkers to predict asthma in wheezing preschool children

Bannier

Kant

Jöbsis

et al. 2015

Clin Experimental Allergy

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Wheezing in preschool children is a very common symptom. An adequate prediction of asthma in these children is difficult and cannot be reliably assessed with conventional clinical tools. The study of potential predictive biomarkers in various media, ranging from invasive sampling (e.g. bronchoscopy) to non-invasive sampling (lung function testing and exhaled breath analysis), was comprehensively reviewed. The evolution in biomarker discovery has resulted in an 'omics' approach, in which hundreds of biomarkers in the field of genomics, proteomics, metabolomics, and 'breath-omics' can be simultaneously studied. First, results on gene expression and exhaled breath profiles in predicting an early asthma diagnosis are promising. However, many hurdles need to be overcome before clinical implementation is possible. To reliably predict asthma in a wheezing child, probably a holistic approach is needed, combining clinical information with blood sampling, lung function tests, and potentially exhaled breath analysis. The further development of predictive, non-invasive biomarkers may eventually improve an early asthma diagnosis in wheezing preschool children and assist clinicians in early treatment decision-making.

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Eosinophil counts and urinary eosinophil protein X in children hospitalized for wheezing during the first year of life: prediction of recurrent wheezing

Abstract: Children with severe wheezing during the first year of life and subsequent recurrent wheezing are characterized by a normal or high eosinophil count in response to viral infections.

Cited by 24 publications

References 28 publications

Outcome of wheezing in early childhood

Outcome of wheezing in early childhood

Respiratory Viruses, Eosinophil Activation, and Early Allergen Sensitization - Early Life Predictors of Persistent Wheezing and Asthma

Biomarkers to predict asthma in wheezing preschool children

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