Eosinophil-Derived Neurotoxin Versus Immunoglobulin E as Biomarkers for Evaluation of Bronchial Asthma

Bronchial Allergen Challenge in Allergic Children: Continuous Increase of Nitric Oxide in Exhaled Air 72 Hours After Allergen Inhalation Independent of Bronchial Obstruction

“…According to several recently published studies, it is more accurate biomarker of the asthma severity in children than other molecules, that were previously considered diagnostic standards. (22,23) In our study baseline values of EDN were elevated in subjects with hyperreactivity characteristic of asthma (PC 20 FEV1 <8 mg/mL) and dual asthmatic reaction to BAC. Also, the relative increase in FeNO following allergen inhalation was the highest in these subjects suggesting indirectly that higher baseline levels of EDN are associated more intense allergic process.…”