Eosinophil lysis and plasma extravasation

Persson, C G

doi:10.1183/09031936.97.10102438

Cited by 8 publications

(2 citation statements)

References 8 publications

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“…An increase in serum ECP may also be involved in the rise of vascular permeability at altitude due to liberation of histamine from mast cells and eosinophils, 21 causing acute altitude-related disorders. Although a potential link between tissue eosinophils and plasma exudation mechanisms in vivo has been observed, 22 such a relationship remains speculative.…”

Section: Discussionmentioning

confidence: 99%

Prolonged Endurance Challenge at Moderate Altitude

Domej

Schwaberger

Tilz³

et al. 2002

Chest

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Section: Discussionmentioning

confidence: 99%

Prolonged Endurance Challenge at Moderate Altitude

Domej

Schwaberger

Tilz³

et al. 2002

Chest

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“…It has already been shown that instructing the patient to take a ‘forceful and deep’ inhalation optimizes the use of DPIs [3]. …”

Section: Introductionmentioning

confidence: 99%

Inspiratory Muscle Training May Increase Peak Inspiratory Flow in Chronic Obstructive Pulmonary Disease

Weiner

2006

Respiration

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Background: When choosing a specific inhalation device for a chronic obstructive pulmonary disease (COPD) patient, the internal airflow resistance and the ability of the patient to overcome it and to create an optimal inspiratory flow are essential. Objectives: The purpose of the present study was to investigate: (1) the peak inspiratory flow (PIF) that a patient with COPD can generate while breathing through two dry powder inhalers and (2) whether in patients with low PIF specific inspiratory muscle training (SIMT) will increase the PIF and exceed the minimal PIF that is considered necessary to guarantee optimal lung deposition of the drug. Methods: Inspiratory muscle strength and PIFs were measured in 60 patients with COPD. Then 28 patients with severe COPD and low PIF were randomized to receive SIMT or to a control group. Results: With the Turbuhaler, 12 patients (20%) could not generate the optimal flow of 60 l/min. PIF correlated very well with maximal inspiratory mouth pressure (PI_max) for the Diskus and the Turbuhaler, as well as for both males and females (p < 0.001). Following the training period, there was a statistically significant increase in the PI_max in the training group. This increase was associated with a significant increase in the PIF. All patients overcame the minimal threshold PIF following the training. Conclusions: Some patients with severe COPD are not able to generate adequate flow to secure optimal lung deposition of the inhalation with the Turbuhaler. SIMT improves inspiratory muscle strength as well as PIF. Following 8 weeks of training, the optimal PIF enabling adequate lung deposition of the drug was attained in all the trained patients.

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Piek inspiratoire stroom door Diskus en Turbuhaler

Palen¹

2001

HUWE

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Eosinophil lysis and plasma extravasation

Cited by 8 publications

References 8 publications

Prolonged Endurance Challenge at Moderate Altitude

Prolonged Endurance Challenge at Moderate Altitude

Inspiratory Muscle Training May Increase Peak Inspiratory Flow in Chronic Obstructive Pulmonary Disease

Piek inspiratoire stroom door Diskus en Turbuhaler

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