Eosinophil/Neutrophil/Platelet-to-Lymphocyte Ratios in Various Types of Immediate Hypersensitivity to NSAIDs: A Preliminary Study

Abstract

Background: The eosinophil/neutrophil/platelet-to-lymphocyte ratios (ELR, NLR, and PLR) have been used as clinical markers of systemic inflammation. However, they have not yet been tested in various subtypes of immediate hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs). Objectives: To assess the ELR, NLR, and PLR in various types of hypersensitivity to NSAIDs. Materials and Methods: A retrospective analysis of complete blood cell count and the ELR, NLR, and PLR was performed. Appropriate types of hypersensitivity to NSAIDs were diagnosed based on the anamnesis and drug provocation tests. The analysis covered 97 patients. Twenty were diagnosed with NERD (NSAID-exacerbated respiratory disease), 20 with NECD (NSAID-exacerbated cutaneous disease), 38 with NIUA (NSAID-inducted urticaria/angioedema), and 19 with SNIUAA (single-NSAID-induced urticaria/angioedema or anaphylaxis). Two controls groups were included: the first covered 15 patients with bronchial asthma and the second 28 patients with chronic spontaneous urti-caria without NSAID hypersensitivity. Results: The NLR did not differ significantly between the NSAID hypersensitivity types. The ELR was significantly higher in NERD patients, and the PLR was significantly lower in NECD patients than in patients with other types of NSAID hypersensitivity and in controls. Conclusions: The ELR and PLR may be useful in differentiating various types of immediate hypersensitivity to NSAIDs. Moreover, the ELR may be helpful in differentiating patients with bronchial asthma with and without NSAID hypersensitivity and PLR in differentiating patients with chronic spontaneous urticaria from NECD.

The Impact of Peripheral Eosinophil Counts and Eosinophil to Lymphocyte Ratio (ELR) in the Clinical Course of COVID-19 Patients: A Retrospective Study

“…A high ELR is associated with cigarette smoking and may be useful indicator of systemic inflammation activity, even in healthy smokers (12). The ELR has been reported to be helpful in differentiating patients with bronchial asthma with and without nonsteroidal antiinflammatory drug (NSAID) hypersensitivity (13). Moreover, increased ELR portend worse overall survival in endometrial cancer, especially in patients characterized as a high-risk group (14).…”

Evaluation of the Relationship Between Hyperemesis Gravidarum With Hemoglobin to Red Cell Distribution Width Ratio and Eosinophil to Lymphocyte Ratio

“…It has been said that it may be a useful indicator of systemic disease [36]. It has been reported that ELR helps in distinguishing those with and without hypersensitivity to non steroidal anti in ammatory drugs in patients with bronchial asthma [37]. In addition, it has been reported that increased ELR level worsens the survival of endometrial cancer and is associated with the high risk group [38].…”

Role of Leukocytes Ratio in Predicting Survival with COVID-19

“…An increased ELR is found in patients with cigarette smoking which can be a beneficial sign of systemic inflammatory activity 13 . Another study reported that the ELR may be supportive to differentiate patients with bronchial asthma with and without non-steroidal anti-inflammatory drugs (NSAIDs) 14 . Therefore, the present study was aimed at evaluating the association of eosinophils, eosinophils to lymphocytes ratio, and lymphocyte to monocyte ratio with Covid-19 patients.…”