Eosinophile Infiltration in the Pancreas of Infants of Diabetic Mothers: A Clinicopathologic Study

Silverman, Jerome L.

doi:10.2337/diab.12.6.528

Cited by 30 publications

(9 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Infiltration of islets by eosinophils has been previously reported in infants of diabetic mothers. 32 The presence of these cells could be considered consistent with the concept of amyloid being depositions of immunoglobulin. Lymphocytic infiltration of hyalinized islets in cats has been reported infrequently, 2 -11 but this was not apparent in the two cats studied in this report.…”

Section: Discussionmentioning

confidence: 78%

Light and Electron Microscopic Studies of Islet Amyloid in Diabetic Cats

Johnson

Stevens

1973

Diabetes

View full text Add to dashboard Cite

The light and electron microscopic characteristics of hyaline deposits present in the pancreatic islets of two aged diabetic cats are described. The hyaline deposits were consistent with amyloid when sections stained with periodic acid-Schiff (PAS), crystal violet, Puchtler's Congo red, and Masson's trichrome were examined by bright field illumination. Green birefringence with Congo red-stained sections and red birefringence with toluidine blue-stained sections were apparent with polarized illumination. In addition, fibrillar components typical of amyloid were ultrastructurally demonstrated in these deposits. Hypotheses regarding the cause of localized amyloidosis in pancreatic islets are considered. Future investigation of the pathogenesis of amyloid deposition in feline pancreatic islets is warranted to obtain a better understanding of the pathogenesis of maturity-onset diabetes in man and the cat.

show abstract

Section: Discussionmentioning

confidence: 78%

Light and Electron Microscopic Studies of Islet Amyloid in Diabetic Cats

Johnson

Stevens

1973

Diabetes

View full text Add to dashboard Cite

show abstract

“…Reassayed antibody titers of fractions, performed after five months storage at -18° C, are shown in figure B (broken black bars). In both column electrophoresis experiments (A and B) the antibody remains in the same regions [y ± and y 2 globulins).The insulin-antibody appears in the region between (3 and y globulins, as in the in vivo experiment shown in figure4. On Sephadex filtration the antibody occurs in the second peak (corresponding to 7S protein) in both experiments (C and D).…”

mentioning

confidence: 75%

“…Langerhans of infants born of diabetic mothers, 4 the long established amyloidosis of the islets of Langerhans in association with maturity-onset diabetes, and the more recent report of lymphocytic infiltration of the islets following the injection of homologous insulin, 5 similar to that seen in association with juvenile diabetes, 6 further suggest an etiologic role in diabetes for insulin antibodies.…”

Section: ' 3 (3) Eosinophilia Of the Islets Ofmentioning

confidence: 90%

See 1 more Smart Citation

Studies on Experimental Insulin Immunity: I. Dynamics of Insulin Immunity in the Guinea Pig

Horino

Blumenthal

1966

Diabetes

View full text Add to dashboard Cite

Insulin half life and the formation and characterization of the insulin-binding antibodies have been studied in the guinea pig both in vivo and in vitro. The antigen-antibody complexes have also been studied utilizing cellulose column electrophoresis and Sephadex G-200 column filtration. In addition, a quantitative assay procedure for insulin-binding antibodies has been employed. In normal guinea pigs the injected insulin-I-125 is carried by at least two serum proteins, presumably albumin and an α. globulin, or more specifically 4.5S and 19S proteins. In immune animals the insulin-antibody complexes are represented by a single peak in the (β-γ globulin region on column electrophoresis; they are distinguishable from the uncomplexed antibodies which are 7S γ1 and 7S γ1 globulins. The precipitating insulin antibody also appears to be a 7S globulin. Moreover, the insulin-antibody complexes occur as a single component in the 19S fraction on Sephadex G-200 filtration, and if the complex were a single molecule it would have a molecular weight equivalent of about 630,000. During the immunization process the insulin binding antibody titer increases progressively in association with an elevation of 7S globulin. In most animals during the early stages of immunization the molecular weight of the antibodies appears to be exclusively of the 7S globulin type; however, in two of seven animals there was, in addition, a small amount of insulin antibody of 19S globulin type early during the immunization period. The purpose in estimating a molecular weight equivalent of the insulin-antibody complex relates to the possibility that the distinctive features of the angiopathies of diabetes may depend upon certain physicochemical characteristics of this complex.

show abstract

“…Macropolynesia, due mainly to an increased number of B cells, is a classical feature of the pancreas in infants of diabetic mothers. Macropolynesia has also been found in babies affected by anti-D-erythroblastosis and by haemolysis due to alpha-thalassaemia [6,9,11,25,30,31,34,37,38,39,41,42], but it has not been proven that in these latter conditions it is also due to an hyperplasia of the B cells [2,5]. The purpose of this paper is to report our findings with different staining techniques on the c}~ological composition of the islets of the human newborns and its variations in different pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

La composition cytologique du pancréas endocrine foetal dans les conditions normales et pathologiques

Assche

Gepts

1971

Diabetologia

View full text Add to dashboard Cite

Summary. The islets of Langerhans of the neonatal pancreas are composed of B cells and non-B cells. The non-B cells are a heterogeneous group and the composition appears to vary according to the staining method used. Silver impregnation methods sometimes impregnate a small number of B cells. No complete identity exists between argyrophilic cells (Hellerstr6m-Hellmaa~ modifications of the Davenport technique) and D cells. In babies from mothers with reduced carbohydrate tolerance the islets contain an increased proportion of B cells and Ag+ cells. Such an increase is not found in babies with erythroblastosis or alpha-thalassaemia. An active hypothalamohypophyseal system seems to be obligatory for complete maturation of the foetal islet tissue. In babies of diabetic mothers hyperplasia of the B cell appears only when a complete hypothalamo-hypophyseal system is present. La composition cytologique du panergas endocrine foetal dans les conditions normales et pathogogiquesRgsumg. Les riots de Langerhans du pancr4as n@onatM sont compos@s de cellules Bet de eellules non-B. Les cellules non-B torment un troupe h4t6rog@ne, dont la composition varie selon la technique de coloration. L'impr6-gnation argentique marque un petit hombre de eetIules B. tl n'y a pas d'6quivMenee entre les eellules argyrophiles (modifications de HellerstrSm et Hellman de la technique de Davenport) et les eellules D. I1 existe une augmentation du rapport eellules Bet eellnles argcntaffines dans les riots de Langerhans d'enfants dont la mgre prgsente un m6ta-bolisme glucidique perturb6. Ce ph4nom6ne n'a pas pu @tre mis en 4vidence chez les enfants pr6sentanfi de ]'6ry-throblastose ou de l'alpha thalass6mie. On pent admettre la ngcessit4 d'un syst~me hypothMamo-hypophysaire actif pour la maturation complgte des riots fo4taux. On eonstate chez les enfants de m@res diab@tiques une hyperplasie des cellules B lorsqu'un syst@me hypothalamo-hypophysaire complet est pr6sent.

show abstract

Eosinophile Infiltration in the Pancreas of Infants of Diabetic Mothers: A Clinicopathologic Study

Cited by 30 publications

References 12 publications

Light and Electron Microscopic Studies of Islet Amyloid in Diabetic Cats

Light and Electron Microscopic Studies of Islet Amyloid in Diabetic Cats

Studies on Experimental Insulin Immunity: I. Dynamics of Insulin Immunity in the Guinea Pig

La composition cytologique du pancréas endocrine foetal dans les conditions normales et pathologiques

Contact Info

Product

Resources

About