Eosinophilia and multiple lymphadenopathy: Kimura disease, a rare, but benign condition

Carretero, Rafael; Brugera, Marta Romero; Rebollo-Aparicio, Noelia; Vázquez-Gómez, Óscar

doi:10.1136/bcr-2015-214211

Cited by 12 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kimura disease may represent a primary inflammatory process with secondary vascular proliferation. [9] There are problems in diagnosis in ephiteloid hemangioma, specially in cases with metaplastic bone formation like in our case. In those cases we should consider in differential diagnosis epithelioid hemangioendothelioma (EHE), epithelioid angiosarcoma (EA), and metastatic carcinoma.…”

Section: Discussionmentioning

confidence: 67%

Clinical and hystopathological dilemmas in diagnosis of epitheloid hemangioma of maxillae-case report

2018

ijdrr

View full text Add to dashboard Cite

Clinical and hystopathological dilemmas in diagnosis of epitheloid hemangioma of maxillae-case report Epithelioid hemangioma (EH) is a rare benign tumor involving the blood vessels and surrounding epithelioid cells. Epitheloid hemangioma, also called histiocytoid hemangioma, angiolymphoid hyperplasia with eosinophilia (ALHE), is a very rare benign tumor in maxillofacial region. There is a controversy in regards to correct diagnosis of an epithelioid hemangioma (EH), particularly when arising in skeletal locations, because of aggressive clinical characteristics, including multifocal presentation and occasional lymph node involvement. Specifically, its distinction from epithelioid hemangio-endothelioma (EHE) has been controversial. In literature we did not find a case where EH involves maxilla. However, there are few cases reported in which EH involved maxillary sinus and nasal cavity. We will present a case of 21 year old male, who came to our Department with a lesion in frontal maxillary region. He underwent surgery four times, wide excision, and with four different histopathology results. The last result was ephiteloid hemangioma with metaplastic bone formation-a very rare benign lesion in oral region, but clinically with very aggressive nature.

show abstract

Section: Discussionmentioning

confidence: 67%

Clinical and hystopathological dilemmas in diagnosis of epitheloid hemangioma of maxillae-case report

2018

ijdrr

View full text Add to dashboard Cite

show abstract

“…Hence, the clinical differential diagnosis may include connective tissue disorders, idiopathic hypereosinophilia, viral hepatitis, Churg-Strauss syndrome, and Kimura disease. 35,36 A detailed clinical history, including anti-nuclear antibody and anti-neutrophil cytoplasmic antibody serology tests, would be very helpful to reach a correct diagnosis of DRESS syndrome and exclude other entities such as idiopathic hypereosinophilia, viral hepatitis, and Kimura disease. In addition, the pathologic features of lymph node biopsy in Churg-Strauss syndrome and Kimura disease are also characteristic.…”

Section: Discussionmentioning

confidence: 99%

Morphologic Spectrum of Lymphadenopathy in Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome

Chen

Wang

Tsai

et al. 2021

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Context.— Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DRESS) is a drug-induced, adverse T-cell–mediated hypersensitivity reaction that most often involves skin. The pathologic findings of DRESS-related lymphadenopathy have been described infrequently in the literature. Objective.— To present a case series of DRESS-related lymphadenopathy with an emphasis on the morphologic spectrum. Design.— We describe detailed clinical and pathologic findings along with the literature review. We focus on the differential diagnosis between DRESS lymphadenopathy and angioimmunoblastic T-cell lymphoma (AITL). Results.— There were 4 men and 1 woman with a mean age of 41 years (range, 23–59 years). One patient (20%) died. Three lymph node biopsy specimens showed a pattern reminiscent of AITL (AITL-like pattern) and 2 cases showed necrotizing lymphadenitis (Kikuchi-like pattern), associated with vasculitis in 1 case. The AITL-like morphology of DRESS-related lymphadenopathy may be difficult to distinguish from genuine AITL. The clinical information is important for differential diagnosis, including history of drug exposure, age, and the rarity or absence of AITL-associated manifestations such as hemolytic anemia and hypergammaglobulinemia. Molecular analysis of the T-cell receptor genes is helpful, typically revealing a polyclonal pattern in DRESS-related lymphadenopathy. Conclusions.— In the literature, 4 histologic patterns of DRESS lymphadenopathy have been described: reactive lymphoid hyperplasia, necrotizing lymphadenitis, Hodgkin lymphoma–like, and AITL-like. These patterns, particularly those that resemble lymphoma, highlight the importance of correct diagnosis to avoid unnecessary therapies.

show abstract

“…Additionally, two groups simultaneously identified angiolymphoid hyperplasia in KD case reports (5,6). Furthermore, in some cases, eosinophilia and multiple lymphadenopathy have consistently been found to be partly associated with KD occurrence (7). While some histological identifications help characterize KD, more clinical features of this disease are needed for a differential diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Clinical analysis of Kimura’s disease in 24 cases from China

Zhang

Qi²,

et al. 2019

Preprint

View full text Add to dashboard Cite

Background We reviewed details of Chinese Kimura’s disease (KD) cases. A full clinical analysis was subsequently performed to improve the accuracy of clinical diagnosis and treatment of KD. Methods A total of 24 patients with pathologically confirmed KD treated between March 2008 and March 2018 were reviewed retrospectively for clinical and histopathological analysis. Results In the 24 KD cases, 20 were male and 4 were female with the age of onset ranging from 5 to 65 years. Lesion diameter ranged from 0.6 cm to 7 cm with unilateral involvement being more popular (79%). Imaging examination had a high detection rate for KD involving the parotid gland and subcutaneous but had low specificity. Microscopic analysis indicated that KD mainly involved subcutaneous soft tissue and lymph nodes. The prominent feature of lymphoid tissue was germinal center hyperplasia surrounded by several lobules associated with hyperplastic vascular structures. Out of the 24 patients, 11 experienced recurrence of disease after treatment (surgical resection: 46.2%, surgical resection followed by oral corticosteroids: 71.4% and surgical resection combined with radiotherapy: 0%). Conclusions Our analysis revealed clinical, imaging, and histological characteristics of KD. A better understanding of the disease will help clinicians reduce misdiagnosis and improve the diagnostic rate upon patient first clinical visit.

show abstract

Eosinophilia and multiple lymphadenopathy: Kimura disease, a rare, but benign condition

Cited by 12 publications

References 14 publications

Clinical and hystopathological dilemmas in diagnosis of epitheloid hemangioma of maxillae-case report

Clinical and hystopathological dilemmas in diagnosis of epitheloid hemangioma of maxillae-case report

Morphologic Spectrum of Lymphadenopathy in Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome

Clinical analysis of Kimura’s disease in 24 cases from China

Contact Info

Product

Resources

About