Eosinophilia Correlates With the Presence or Development of Chronic Graft-Versus-Host Disease in Children

Jacobsohn, David A.; Schechter, Tali; Seshadri, Roopa; Thormann, K.; Duerst, R.; Kletzel, Morris

doi:10.1097/01.tp.0000118409.92769.fa

Cited by 49 publications

(36 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10,19,20 In our study, patients with skin cGVHD had a significantly higher mean peak peripheral eosinophil count than control patients, with a mean time of onset of eosinophilia of 54 days before the symptoms of cGVHD. Patients with sclerotic cGVHD were more likely to have preceding eosinophilia than those with nonsclerotic disease.…”

Section: Demographicsmentioning

confidence: 75%

Nail dystrophy, edema, and eosinophilia: harbingers of severe chronic GVHD of the skin in children

Huang

Duncan

Boyer

et al. 2014

Bone Marrow Transplant

View full text Add to dashboard Cite

The prognostic value of adnexal findings in chronic GVHD (cGVHD) has not been investigated in children. Dermatologic examinations were performed in a severe cohort of 11 children with skin cGVHD seen over a 2-year period. Findings were compared with 25 additional patients with skin cGVHD and 97 control patients. In 36 patients with skin cGVHD, nail dystrophy was present in 45% of patients, and was significantly associated with sclerotic disease and lung cGVHD. Pterygium inversum unguis (PIU) was associated with severe lung disease, with significantly lower % predicted FVC and FEV1 in those with PIU than those without. Forty-four percent of GVHD patients had preceding peripheral edema and 56% had preceding peripheral eosinophilia. Peripheral edema and eosinophilia were significantly associated with sclerotic cGVHD and persisted until the diagnosis of cGVHD in all patients. Comparison of data with control patients showed that incidence of nail dystrophy, incidence of peripheral edema and mean peak peripheral eosinophil count of patients with skin cGVHD was significantly higher than those without cGVHD. This study suggests that nail dystrophy, persistent peripheral edema and persistent peripheral eosinophilia are harbingers of severe cGVHD of the skin in children. The presence of PIU may be a harbinger of severe lung involvement.

show abstract

Section: Demographicsmentioning

confidence: 75%

Nail dystrophy, edema, and eosinophilia: harbingers of severe chronic GVHD of the skin in children

Huang

Duncan

Boyer

et al. 2014

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…Eosinophilia in the blood and tissue is a common feature of GvHD and contributes to the allogeneic response, as revealed in investigations of GvHD in animal models (73,74). Studies have shown that eosinophilia is a predictor for acute and chronic GvHD (75,76). However, the prognostic significance remains controversial, as some studies have shown a favorable correlation with survival (77)(78)(79) and others have shown the opposite effect (80).…”

Section: Graft-versus-host Diseasementioning

confidence: 98%

Eosinophils and Cancer

Davis

Rothenberg

2014

Cancer Immunology Research

224

171

View full text Add to dashboard Cite

Eosinophils have long been known to infiltrate tumors, and in most cases, this is associated with an improved prognosis. However, the reasons behind this infiltration and the mechanism of action of the eosinophil have remained elusive. In this article, we explore the biology of eosinophils and examine their function in homeostasis and disease states, specifically focusing on what is currently known about the association of the eosinophil with cancer. Cancer Immunol Res; 2(1); 1-8. Ó2014 AACR. Disclosure of Potential Conflicts of InterestM.E. Rothenberg has an ownership Interest in Immune Pharmaceuticals and Receptos; is a consultant/advisory board member of Immune Pharmaceuticals, Norvatis, Pluristem Therapeutics, and Receptos; and has royalty to reslizumab (Teva Pharmaceuticals). No potential conflicts of interest were disclosed by the other author. CME Staff Planners' DisclosuresThe members of the planning committee have no real or apparent conflicts of interest to disclose. Learning ObjectivesEosinophils, discovered over 150 years ago, are present in various lesions, and tumor-associated tissue eosinophilia has been correlated with both good and bad prognosis for cancer. Upon completion of this activity, the participant should gain a basic knowledge of the biology of eosinophils, and their potential roles in homeostasis and in diseases. A broader understanding of these granulocytic leukocytes and their interaction with other immune cells will inform research on their potential to affect tumors and to improve cancer therapy.

show abstract

“…A number of studies, mostly in adults, have shown that thrombocytopenia at the time of chronic GVHD diagnosis confers a poor prognosis (Sullivan et al, 1988a;Akpek et al, 2001b). Eosinophilia is often seen in children with chronic GVHD and sometimes precedes the occurrence of chronic GVHD (Jacobsohn et al, 2004). Eosinophilia usually resolves with adequate systemic treatment of GVHD.…”

Section: Haematopoietic Systemmentioning

confidence: 99%

Optimal management of chronic graft‐versus‐host disease in children

Jacobsohn

2010

Br J Haematol

Self Cite

View full text Add to dashboard Cite

SummaryChronic graft-versus-host disease (GVHD) is a major complication after allogeneic haematopoietic stem cell transplantation (HSCT). Not only is it the major cause of late mortality in HSCT patients, but it also accounts for significant morbidity. Much of the literature on chronic GVHD has focused on adults. Chronic GVHD is of major importance in children, especially since they have years to live following the complications of chronic GVHD and its therapy. The goal is to review incidence, manifestations, and therapies, especially when applicable to the paediatric population.

show abstract

Eosinophilia Correlates With the Presence or Development of Chronic Graft-Versus-Host Disease in Children

Cited by 49 publications

References 11 publications

Nail dystrophy, edema, and eosinophilia: harbingers of severe chronic GVHD of the skin in children

Nail dystrophy, edema, and eosinophilia: harbingers of severe chronic GVHD of the skin in children

Eosinophils and Cancer

Optimal management of chronic graft‐versus‐host disease in children

Contact Info

Product

Resources

About