Eosinophilia in Dermatologic Disorders

Graauw, Elisabeth Louisa de; Beltraminelli, Helmut; Simon, Hans‐Uwe; Simon, Dagmar

doi:10.1016/j.iac.2015.05.005

Cited by 33 publications

(21 citation statements)

References 81 publications

(116 reference statements)

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“…Lung-resident eosinophils represent a distinct regulatory eosinophil subset Claire Mesnil, 1,2 Stéfanie Raulier, 1 Geneviève Paulissen, 1 Xue Xiao, 2,3 Mark A. Birrell, 4 Dimitri Pirottin, 1,2 Thibaut Janss, 1 Philipp Starkl, 5 Eve Ramery, 2 Monique Henket, 6,7 Florence N. Schleich, 6,7 Marc Radermecker, 8 Kris Thielemans, 9 Laurent Gillet, 2,3 Marc Thiry, 10 Maria G. Belvisi, 4 Renaud Louis, 6,7 Christophe Desmet, 1,2 Thomas Marichal, 1,2 and Fabrice Bureau plemental Figure 2), suggesting that they were undergoing piecemeal degranulation, a process during which granule proteins are released gradually (34,35). Some low-density granules displayed a central structure that most likely corresponded to the central MBP-containing core typical of eosinophil granules (34,35), and contained intragranular vesiculotubular structures previously delineated within human eosinophilic granules (35) (Supplemental Figure 2, arrows and arrowheads, respectively).…”

Section: Cd101mentioning

confidence: 99%

“…Among these, the Th2-associated cytokine IL-5 is the most specific cytokine for the eosinophil lineage and is responsible not only for expansion of eosinophils from committed BM progenitors, but also for their release into the blood and their survival following migration into the tissues (1,8,9). Once at the site of injury, eosinophils can release their cytotoxic granule proteins as well as preformed cytokines and lipid mediators, contributing in certain circumstances to parasite destruction, but also to exacerbation of inflammation and tissue damage, which is particularly deleterious when Th2 responses are directed against allergens (1,8,10). It is interesting to note that the role of eosinophils is not limited to the effector phase of Th2 responses but also seems to be important for the induction of adaptive immunity.…”

Section: Introductionmentioning

confidence: 99%

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Lung-resident eosinophils represent a distinct regulatory eosinophil subset

Mesnil

Raulier

Paulissen

et al. 2016

Journal of Clinical Investigation

432

506

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Increases in eosinophil numbers are associated with infection and allergic diseases, including asthma, but there is also evidence that eosinophils contribute to homeostatic immune processes. In mice, the normal lung contains resident eosinophils (rEos), but their function has not been characterized. Here, we have reported that steady-state pulmonary rEos are IL-5-independent parenchymal Siglec-FintCD62L+CD101lo cells with a ring-shaped nucleus. During house dust mite-induced airway allergy, rEos features remained unchanged, and rEos were accompanied by recruited inflammatory eosinophils (iEos), which were defined as IL-5-dependent peribronchial Siglec-FhiCD62L-CD101hi cells with a segmented nucleus. Gene expression analyses revealed a more regulatory profile for rEos than for iEos, and correspondingly, mice lacking lung rEos showed an increase in Th2 cell responses to inhaled allergens. Such elevation of Th2 responses was linked to the ability of rEos, but not iEos, to inhibit the maturation, and therefore the pro-Th2 function, of allergen-loaded DCs. Finally, we determined that the parenchymal rEos found in nonasthmatic human lungs (Siglec-8+CD62L+IL-3Rlo cells) were phenotypically distinct from the iEos isolated from the sputa of eosinophilic asthmatic patients (Siglec-8+CD62LloIL-3Rhi cells), suggesting that our findings in mice are relevant to humans. In conclusion, our data define lung rEos as a distinct eosinophil subset with key homeostatic functions

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Section: Cd101mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lung-resident eosinophils represent a distinct regulatory eosinophil subset

Mesnil

Raulier

Paulissen

et al. 2016

Journal of Clinical Investigation

432

506

View full text Add to dashboard Cite

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“…Eosinophils are found in a broad spectrum of infectious and noninfectious skin diseases, despite the fact that the skin is devoid of eosinophils under physiologic conditions . Eosinophils are under the control of eosinophil haematopoietins; in particular, interleukin (IL)‐5 plays a critical role in regulating the production, differentiation, activation, trafficking and survival of eosinophils .…”

mentioning

confidence: 99%

Evidence for a role of eosinophils in blister formation in bullous pemphigoid

Graauw

Sitaru

Horn

et al. 2017

Allergy

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Our results provide evidence that IL-5-activated eosinophils directly contribute to BP blister formation in the presence of BP autoantibodies. Dermal-epidermal separation by IL-5-activated eosinophils depends on adhesion and Fcγ receptor activation, requires elevated ROS production and degranulation and involves EET formation. Thus, targeting eosinophils may be a promising therapeutic approach for BP.

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“…For example, tissue eosinophilia is present in and tightly associated with the inflammation of the airway in asthma [27] and rhinosinusitis [28], of the gastrointestinal tract in eosinophilic esophagitis (EoE) [29,30] and eosinophilic gastroenteritis [31,32], and of the skin lesions in atopic dermatitis [33].…”

Section: Pro-inflammatory and Destructive Effects In Allergic Inflammmentioning

confidence: 99%