Eosinophilia in patients undergoing dialysis.

Montolíu, J; López-Pedret, J; Andreu, Lola; Revert, Li.

doi:10.1136/bmj.282.6282.2098

Cited by 23 publications

(15 citation statements)

References 2 publications

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“…Patients on maintenance hemodialysis have sometimes developed eosinophilia . The mechanisms of hemodialysis‐related eosinophilia are not fully understood.…”

Section: Discussionmentioning

confidence: 99%

“…Patients on maintenance hemodialysis have sometimes developed eosinophilia. 7 The mechanisms of hemodialysis-related eosinophilia are not fully understood. However, it may involve a kind of allergic reaction against sterilizing agents of the dialyzers, including ethylene oxide, 20 and the dialysis membrane itself.…”

Section: Discussionmentioning

confidence: 99%

“…5 hemodialysis materials, and present clinical manifestations including itching, urticarial eruption, and blood eosinophilia. 6,7 To date, a few cases of BP [8][9][10][11][12] and pemphigoid nodularis 13 have been reported in patients treated with hemodialysis. Here we describe a case of BP, in which blood eosinophilia and bullous eruption appeared after the use of cellulose membrane for hemodialysis, and resolved after withdrawal of the membrane.…”

Section: Introductionmentioning

confidence: 99%

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Development of bullous pemphigoid after change of dialysis membrane

Sodemoto

Yamahana

Echigo

et al. 2013

Hemodialysis International

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A 75-year-old Japanese man presented with pruritic blisters and macules on his trunk and extremities. He had been on hemodialysis for 4 years because of chronic renal failure, and in recent months, a polymethylmethacrylate membrane had been used for dialysis. After a change in dialysis membrane to a cellulose triacetate membrane, pruritic tense blisters developed on the extremities in combination with marked blood eosinophilia. Physical examination showed erythematous macules and tense blisters on the trunk and extremities. A biopsy specimen of an erythematous macule showed subepidermal vesicles and eosinophils that attached to the dermal-epidermal junction. Serum level of eosinophilic cationic protein was elevated. From clinical, histological, and immunological findings, a diagnosis of bullous pemphigoid was made. New blisters continued to erupt during the period in which the patient used the cellulose triacetate membrane dialyzer, and even after the use of clobetasol propionate. It resolved only after the patient came back to the use of a synthetic membrane dialyzer. We discontinued the use of clobetasol propionate, and neither bullous eruptions nor blood eosinophilia recurred. These observations suggest that cellulose membrane may be involved in the development of bullous pemphigoid through activation of eosinophils in the blood and the skin lesion, as in the present case.

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“…Patients on maintenance hemodialysis have sometimes developed eosinophilia . The mechanisms of hemodialysis‐related eosinophilia are not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of bullous pemphigoid after change of dialysis membrane

Sodemoto

Yamahana

Echigo

et al. 2013

Hemodialysis International

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“…Eosinophilia is found in various diseases, including allergies, and is known as a complication that can occur in patients on hemodialysis or peritoneal dialysis (1)(2)(3)(4)(5)(6)(7).…”

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confidence: 99%

A Case Report of Hemodialysis Intolerance With Eosinophilia

et al. 2007

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We report the case of a patient who developed eosinophilia during hemodialysis and became intolerant to dialysis therapy. The patient, a 40-year-old woman, was initiated on hemodialysis for end-stage renal failure caused by chronic glomerulonephritis. After starting on dialysis, her eosinophil count gradually increased. During the ninth session, she developed abdominal pain of an unknown cause after approximately 1 h of dialysis. The symptom, which persisted in the following sessions, was considered to be a dialysis-related complication. We attempted different dialyzers and anticoagulants, but without improvement. The dialysis therapy was discontinued and steroid treatment was given. The hypereosinophilic condition improved rapidly and dialysis therapy was restarted successfully without causing abdominal pain. To investigate the cause of this problem, we measured the leukocyte count and anaphylatoxin C3a level in peripheral blood during dialysis, and compared the results before and after steroid treatment. The results showed that the significant decrease in the leukocyte count observed before steroid treatment was reduced to a mild decrease after steroid treatment. In contrast, C3a did not show a significant difference between the values obtained before and after steroid treatment. These findings suggest that eosinophilia played an important role in the etiology of dialysis intolerance and that C3a was not involved in the decrease in leukocytes under the conditions experienced by the present patient.

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“…Clinically, dialysis eosinophilia is symptomless and may be persistent or intermittent [2]. Most often it is considered as a benign laboratory abnormality that does not necessarily result in increased morbidity [3]. On the other hand, Kimura's disease (KD) is an allergic, inflammatory disorder of unknown cause [4].…”

Section: Introductionmentioning

confidence: 99%

Kimura’s Disease in a Chronic Hemodialysis Patient

Lee

Huang²,

Lam³

et al. 2001

Am J Nephrol

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Eosinophilia is not an uncommon finding in chronic dialysis patients. It is usually benign in nature although definite pathogenesis is unknown. We have encountered a young uremic Chinese adult who developed Kimura’s disease after being on maintenance hemodialysis for about 3 years. Asymptomatic eosinophilia had been noted for 1 year and 8 months prior to the development of progressively enlarged neck masses, which leads to the diagnosis of Kimura’s disease. In contrast to most cases, eosinophilia was first noticed before the neck masses appeared. There is often a close correlation between Kimura’s disease and glomerular disease, where renal involvement is considered as a systemic manifestation. However, we do not have strong evidence to support this relationship between terminal renal failure and Kimura’s disease in this patient. To our knowledge, our patient is the first reported case of Kimura’s disease occurring in chronic hemodialysis patients. Eosinophilia persisted for nearly 2 years before the neck mass developed and recurred after the excision. Besides, our patient also demonstrated a chronic and recurrent course typical of Kimura’s disease.

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Eosinophilia in patients undergoing dialysis.

Abstract: oxalate, 10 % magnesium ammonium phosphate, and the remainder calcium phosphate), but she has apparently made no more. Biochemical progress is shown in the figure.

Cited by 23 publications

References 2 publications

Development of bullous pemphigoid after change of dialysis membrane

Development of bullous pemphigoid after change of dialysis membrane

A Case Report of Hemodialysis Intolerance With Eosinophilia

Kimura’s Disease in a Chronic Hemodialysis Patient

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