Eosinophilia in Peripheral Blood and Inflammatory Exudate in Non‐specific Proctocolitis

Riis, P; Anthonisen, P

doi:10.1111/j.0954-6820.1964.tb00553.x

Cited by 27 publications

(2 citation statements)

References 23 publications

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“…Via this approach, we found that a significant number of eosinophilic episodes were concurrent with active UC or PSC with no other obvious inciting agent such as a new medication, as 31.3% of EoUC patients had blood eosinophilia during known UC flares, which is similar to previous reports that identified eosinophilia in approximately one-third of UC patients [11,12]. However, we observed that a greater number of eosinophilic episodes occurred immediately after bowel surgery or liver transplantation, suggestive of a possible confounder such as anesthesia or the surgical intervention itself.…”

Section: Discussionsupporting

confidence: 87%

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Recurrent Blood Eosinophilia in Ulcerative Colitis Is Associated with Severe Disease and Primary Sclerosing Cholangitis

et al. 2012

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Background and Aims Eosinophils are implicated in the pathogenesis of inflammatory bowel disease (IBD). A subset of IBD patients develops blood eosinophilia and the clinical profile of these patients is undefined. We sought to characterize IBD patients with and without eosinophilia. Methods We studied a prospective registry of 1176 IBD patients followed in a tertiary referral center. Patients who developed eosinophilia at any time were identified by electronic medical record query. We performed a chart review case-control study comparing patients with recurrent eosinophilia versus randomly selected disease matched patients with no history of eosinophilia. Histological analysis was performed on selected cases and controls. Results Eosinophilia at any time was more prevalent in ulcerative colitis (UC) patients than Crohn’s disease patients (22.2% vs. 12.7%), as was recurrent eosinophilia (3.4% vs. 0.7%). UC patients with recurrent eosinophilia were predominantly male compared to the control UC population (81.3% vs. 46.9%) and had higher rates of colectomy for either medically refractory disease or dysplasia/cancer than control UC patients (56.3% vs. 15.6%). Primary sclerosing cholangitis (PSC) occurred in 37.5% of UC patients with recurrent eosinophilia compared to only 3.1% in the UC controls. Histological analysis of random diagnostic samples from UC patients with recurrent eosinophilia demonstrated a normal eosinophil pattern as seen in the control UC population. Conclusions Eosinophilia-associated UC is a subgroup of IBD associated with severe colitis and PSC. Further studies are warranted to characterize molecular mechanisms underlying eosinophilia-associated UC and to determine optimal approaches for therapy.

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Section: Discussionsupporting

confidence: 87%

“…Early prospective studies of UC demonstrated that approximately one-third of patients with UC have an increase in blood eosinophils during active or relapsing disease [11,12]. It was postulated that UC may be an allergic disorder in these individuals with eosinophilia given the frequent association with eosinophils and allergic disease.…”

Section: Discussionmentioning

confidence: 99%