Eosinophilia secondary to lenalidomide therapy

Escudero‐Vilaplana, Vicente; Osorio-Prendes, Santiago; Collado-Borrell, Roberto; González-Arias, Elena; Sanjurjo‐Sáez, María

doi:10.1111/jcpt.12611

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…Nurrochmad et al observed that CD8 + T cells in peripheral blood were reduced by CTX treatment (150 and 100 mg/kg body weight on days 1 and 4) [ 31 ]. Escudero-Vilaplana reported that CTX caused increase in eosinophils [ 32 ]. Wu et al demonstrated that CTX treatment (140 mg/kg every 6 days) induced reduction of CD8+ T cells in blood while increasing CD8+ T-cell infiltration into tumors [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Jujube Powder Enhances Cyclophosphamide Efficiency against Murine Colon Cancer by Enriching CD8+ T Cells While Inhibiting Eosinophilia

et al. 2021

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Cyclophosphamide (CTX) is widely applied in cancer treatment. However, the outcome is often compromised by lymphopenia, myelosuppression, and gut dysbiosis. Here, we used jujube powder to enhance CTX efficiency through nurturing gut microbiota in order to facilitate favorable metabolisms. It was observed that the oral administration of jujube powder enriched CD8+ T cells in mouse MC38 colon tumor microenvironment and increased the diversity of gut microbiota and the abundance of Bifidobacteriales, which is helpful to the production of butyrate in the cecum content. The application of jujube powder also stimulated the production of white blood cells, especially CD8+ T cells in peripheral and bone marrow, while inhibiting the growth of eosinophils in peripheral blood and the production of IL-7 and GM-CSF in serum. All these are conductive to the significant inhibition of the tumor growth, suggesting the high potential of nurturing gut microbiota with natural products for improving the efficiency of chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Jujube Powder Enhances Cyclophosphamide Efficiency against Murine Colon Cancer by Enriching CD8+ T Cells While Inhibiting Eosinophilia

et al. 2021

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“…7 Palonosetron hydrochloride (INN, trade name Aloxi), for example, is a 5-HT3 receptor antagonist indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). 8 Isoindolinones, or benzofused γ-lactams, are another class of natural products, 9 and are found in the NSAID anti-inflammatory indoprofen, 10 multiple myeloma treatment lenalidomide 11 and antiplatelet drug indobufen. 12 In addition, N -acyl sulfonamides are best known as bacteriostatic and antimalarial agents and are also present in a range of drugs possessing various pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%