Eosinophilic angiocentric fibrosis of orbit

Azam, Muhammad; Husen, Yousuf; Hasan, Sheema H

doi:10.4103/0377-4929.72086

Cited by 10 publications

(10 citation statements)

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“…Primary orbital involvement is very rare and was reported for the first time in 2006 by Leibovitch et al, who described 1 patient with a 6‐week history of proptosis and periorbital edema with no nasal or cutaneous signs. Since then, 4 more cases have been described . In our case, the CT scan and MRI revealed a mass involving both the right orbit and anterior ethmoidal cells.…”

Section: Discussionmentioning

confidence: 69%

“…EAF is a chronic, idiopathic disorder that involves the upper respiratory tract with progressive submucosal perivascular fibrosis of unknown etiology, although allergy and trauma have been suspected. A recent study proposed that EAF might be part of the spectrum of IgG4‐related systemic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Since its initial description in 1983 by Holmes and Panje, approximately 55 cases have been reported in the medical literature. Eight studies on EAF involving the orbit (10 cases) and ocular adnexa (3 cases) have been published previously, and there have been only 5 cases with primary orbital involvement of EAF. We report here another case of primary orbital EAF extending to the ethmoid, and describe its clinical, radiological, and histological features for a better understanding of this rare entity.…”

Section: Introductionmentioning

confidence: 99%

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Primary orbital eosinophilic angiocentric fibrosis with intranasal extension

et al. 2013

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Physicians involved in the treatment of orbital pathologies should be familiar with this entity, because it may manifest as an intraorbital mass growing primarily or secondly into the orbit. The clinical manifestations of eosinophilic angiocentric fibrosis with orbital involvement often mimic other more common ophthalmological diseases. Biopsies are necessary for diagnosis and treatment planning, although cures are usually of palliative effect.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary orbital eosinophilic angiocentric fibrosis with intranasal extension

et al. 2013

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“…Two years later, Roberts and McCann gave the term 'EAF of the upper respiratory tract' to this condition distinguished by inflammatory cell infiltration, predominantly eosinophils, and progressive perivascular fibrosis [6]. To the best of our knowledge, 54 EAF [7][8][9] and only seven cases with orbital involvement including our case have been reported so far [2,8,[10][11][12][13].…”

Section: Discussionmentioning

confidence: 75%

“…Very few EAF cases with orbital involvement and nasolacrimal duct obstruction have been described in the literature. These cases present with periorbital edema and painless proptosis, globe displacement, and limitation in ocular movements, epiphora, diplopia, and eyelid swelling [2,8,[10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Nasal Eosinophilic Angiocentric Fibrosis with Orbital Extension

Faramarzi

Dadgarnia

Moghimi

et al. 2015

Head and Neck Pathol

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Eosinophilic angiocentric fibrosis (EAF) is an extremely rare, chronic, benign, idiopathic disorder that mostly affects the upper respiratory tract, particularly the nasal cavity, and features progressive submucosal perivascular fibrosis. To the best of our knowledge, only seven cases of EAF with orbital involvement have been reported. We report a case of sinonasal EAF with orbital extension that presented with left nasolacrimal duct obstruction. A 35-year-old man presented with left epiphora, proptosis, anterolateral globe displacement and nasal obstruction. Endoscopic sinus examination showed a firm, gritty, creamy, yellow, fibrous, adherent mass of maxillary sinus. Diagnosis was established with histopathological examination of excisional biopsy of the lesion. Although EAF is very rare, it should be considered in the differential diagnosis of lesions of upper airway tract, particularly the nasal cavity. Biopsy is necessary for diagnosis and treatment planning. Resecting of the involved tissues completely is essential for prevention of recurrence.

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