Eosinophilic Annular Erythema: A New Entity of Eosinophilic Dermatosis

Abstract

Eosinophilic annular erythema (EAE) is a rare dermatosis. Its relationship with Wells syndrome (WS) is debated. We report a case treated with hydroxychloroquine.A 31-year-old patient presented with a mildly pruritic rash that had been evolving by flares for two weeks. Clinical examination revealed inflammatory erythematous-annular plaques on the trunk and limbs. The blood count was normal. Skin histology showed an eosinophilic-rich inflammatory infiltrate. After local steroid treatment, the patient was treated with oral steroids with a momentary improvement. The course with new relapses is treated by synthetic antimalarial drugs with the complete disappearance of the lesions at a six-month follow-up.Although some authors consider EAE to be a variant of WS, we believe that there are subtle differences that differentiate them despite their clinical similarity.

A rare case of eosinophilic annular erythema, an uncommon new entity of eosinophilic dermatosis

“…8 Clinical remission with nicotinamide, cyclosporine, dapsone, indomethacin, doxycycline, mycophenolate mofetil, dupilumab and phototherapy also has been reported. 3,4,8,9 A 39-year-old male patient with diffuse EAE was successfully treated with doxycycline 100 mg/ twice daily with substantial resolution of lesions within 3 months, complete clearance within 1 year, but with recurrence after cessation of the drug. Mycophenolate mofitel was reported to clear skin lesions of EAE in a patient with autoimmune hepatitis but was discontinued because of raised liver enzymes.…”

Eritema anular eosinofílico

“…El eritema anular eosinofílico es una dermatosis poco común, aguda, de origen eosinofílico, de curso benigno y recidivante. 1 En la actualidad existe controversia entre si se trata de una entidad separada o un subtipo del Síndrome de Wells. 2…”