Eosinophilic arthritis—A case report

Yamabe, Hideaki; Kudo, Fumiko; Shimada, Michiko

doi:10.1002/ccr3.3737

Cited by 1 publication

(1 citation statement)

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“…It is postulated to be related to direct eosinophil infltration, fbrosis, or thrombosis ultimately afecting a diverse array of organs including the cranial nerves, oesophagus, lungs, kidneys, skin, and heart [10]. As seen in our patient, there have been infrequent reports of polyarthritis occurring with eosinophilia but without evidence of systemic involvement that is characteristically unresponsive to NSAIDS but ameliorated by corticosteroids [11,12]. Te distinction is made in favour of chronic eosinophilic leukemia, not otherwise specifed, when a clonal cytogenetic or molecular genetic abnormality is established, or blast count is ≥ 2% in the peripheral blood or >5% in the bone marrow [2].…”

Section: Discussionmentioning

confidence: 56%

Chronic Eosinophilic Leukemia Presenting as Cardiac Failure

Pepra-Ameyaw

Ghunney

Ampofo

et al. 2022

Case Reports in Hematology

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Chronic eosinophilic leukemia (CEL) is a rare chronic myeloproliferative disorder characterized by sustained eosinophilia. Although the incidence of CEL is uncertain, it can be clinically devastating as it has a propensity to affect several important organ systems. This is of particular significance in Sub-Saharan Africa where helminthic infections are a more prevalent cause of eosinophilia. To the best of our knowledge, we present the first reported case of CEL complicated by cardiac disease in a Ghanaian. He presented with a history of orthopnoea and dyspnoea on exertion, and examination revealed a pansystolic murmur over the mitral region and moderate splenomegaly. Good symptomatic control was achieved using hydroxyurea after which haematologic and cytogenetic remission was achieved after 12 weeks on a tyrosine kinase inhibitor. Physicians working in low resource environments should exclude clonality in patients presenting with eosinophilia and end-organ damage.

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