Eosinophilic cellulitis or Wells’ syndrome in a 6-year-old child

Straaten, Saskia van der; Wojciechowski, Marek; Salgado, Roberto; Menten, Greet; Mees, Nicole; Hagendorens, Margo M.

doi:10.1007/s00431-005-0036-5

Cited by 13 publications

(3 citation statements)

References 9 publications

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“…Blood eosinophilia could be found in more than 50% of the cases (29 of 45 cases; 64%); in these patients, the level of eosinophils fluctuates with the course of the disease, returning to reference range on clinical remission. In only seven cases bullous lesions were present (7,(12)(13)(14)(15)(16). The extremities are most frequently affected, but truncal involvement is also observed.…”

Section: Discussionmentioning

confidence: 99%

Wells� syndrome in childhood: two case reports with review of the literature

Farina¹

2014

CDERM

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SummaryWells' syndrome, or eosinophilic cellulitis, is a rare disorder manifesting with acute erythematous and edematous plaques which resolve completely. Bullous lesions are uncommon, especially in childhood. We present two pediatric cases of bullous Wells' syndrome, one 3-year-old boy with atypical cutaneous manifestations and one 6-month-old girl with typical skin lesions. No trigger factors could be identified in both cases. Treatment with topical and systemic steroids was performed. Both patients had no recurrences after two years. Fortyfive pediatric cases of Wells' syndrome have been reported in the literature with an average age of onset of five years. In only seven cases bullous lesions were present. In about half of the patients a precipitating factor has been identified, including infections, arthropod bites, drug administration and hematologic disorders.

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Section: Discussionmentioning

confidence: 99%

Wells� syndrome in childhood: two case reports with review of the literature

Farina¹

2014

CDERM

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“…The pathogenesis of Wells’ syndrome is unknown, but the currently accepted theory involves a local hypersensitivity reaction to an inciting agent. Triggers include insect bites, medications, immunizations, hematologic disorders, infections, and association with solid tumors (2,4); however, half of all patients lack a known trigger (3), as was the case in our patient. The differential diagnoses include drug reaction, bacterial cellulitis, Churg–Strauss syndrome, idiopathic hypereosinophilic syndrome, and bullous pemphigoid.…”

Section: Discussionmentioning

confidence: 55%

Wells’ Syndrome Presenting as a Noninfectious Bullous Cellulitis in a Child

Shams

Hudgens

Lesher

et al. 2010

Pediatric Dermatology

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“…Second, the subacute stage is characterized by the formation of palisading groups of eosinophils and histiocytes surrounding a core of collagen containing free eosinophilic granules and cellular debris, also known as flame figures. The final (resolution) stage shows gradual disappearance of the eosinophils, leaving histiocytes and giant cells (20) and spider bites (10). As such, a clinical and histopathological correlation is necessary for diagnosis.…”

Section: Discussionmentioning

confidence: 99%