Eosinophilic colitis: clinical review and 2020 update

Abstract

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Eosinophilic Esophagitis With Subsequent Eosinophilic Colitis: Keeping a High Index of Suspicion

“…The pathogenesis appears to be a response to ingested and/or inhaled allergens mediated by T-helper 2 cells in the GI tract leading to eosinophilia, chronic inflammation, and GI symptoms [ 9 ]. Eosinophils are normally present within the rest of the GI tract, making the diagnosis of EGID in distal segments of the GI tract more challenging histopathologically, with the lack of clear threshold values for diagnosis [ 10 ]. Management of EGID focuses on symptomatic, endoscopic, and histological improvement.…”

“…Unlike EoE, initial non-pharmacological treatments in EC, including dietary elimination measures, have been of limited effect in the adult population with mixed data [ 10 ]. Oral steroids remain the mainstay of treatment in many cases of EC [ 5 ].…”

Eosinophilic ulcerative colitis- case report and literaturereview

“…The main differential diagnoses to exclude are parasitic infections (Strongyloides stercoralis, Schistosoma spp, Trichuris trichiura, Angiostrongylus costaricencis, Gnathostoma spp, Ascaris lumbricoides, Ancylostoma caninum, Ascaris suum, Enterobius vermicularis and Dientamoeba fragilis and others), some drugs (such as NSAIDs, carbamazepine, rifampin, enalapril, radiotherapy among others), vascular, connective tissue diseases, celiac disease, malignant conditions, and inflammatory bowel disease (IBD). [1][2][3][4] After excluding secondary causes of EC it is important to associate the clinical and epidemiology of the patient such as higher prevalence in females, family history of allergy and age, as the diagnosis is usually made in the adult aged between 33 and 50 years. 2 Laboratory analysis is limited as it has low specificity and sensitivity, but possible to find peripheral eosinophilia which is often transient.…”

“…Volume 13 Issue 2 -2022 Isabela Bercovici Soares Pereira, 1 Danilo Queiroz Dantas, 1 Taís Donha Yarid Angelieri, 1 Daniel Yuji Tanaka, 1 Eduardo Achar, 2 Francisco Carillo Neto, 3 João Kleber de Almeida Gentile TCBCD 4 with daily watery diarrhea without mucus or blood for 3 months sought treatment. He reported that the symptoms began after treatment for H. pylori 3 months ago, treated with antibiotics (amoxacillin and clarithromycin).…”

“…1,2,3 There is still no consensus on the definition of EC, but taking into consideration recent international literatures, the term ''Eosinophilic Colitis'' is reserved for symptomatic patients, when asymptomatic patients are given the diagnosis of ''Primary Colonic Eosinophilia'', This is still a weak definition as pathologists use it to define a ''higher than normal'' number of eosinophils in the colonic mucosa, as there is in fact no specific value that defines the normal amount of eosinophils in the colonic mucosa. 1,2 Eosinophilic colitis is an uncommon and heterogeneous disease that appears to have a bimodal age distribution, with a first peak in newborns and a second peak in young adults. 3,4 A slight male predominance is observed in this scenario.…”