Eosinophilic Dermatoses: Recognition and Management

Marzano, Angelo Valerio; Genovese, Giovanni

doi:10.1007/s40257-020-00520-4

Cited by 41 publications

(27 citation statements)

References 147 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cutaneous manifestations of LV-HES include pruritus, angioedema, urticaria, eczematous dermatitis, and papular lesions. Patients with LV-HES rarely suffer from palpable purpura and the indurated plaques described in the presented case [30]. In doubtful cases, staining with TFH markers on lymph node biopsy should aid the correct diagnosis [29].…”

Section: Discussionmentioning

confidence: 73%

Fever, rash, and eosinophilia – early signs of angioimmunoblastic T-cell lymphoma

Wawrzycki

Prystupa

Szumiło

et al. 2021

Ann Agric Environ Med.

View full text Add to dashboard Cite

Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon lymphoma of elderly adults with a poor prognosis. AITL patients show systemic symptoms, lymphadenopathy, and not infrequently, skin rash with various dysimmune phenomena rashes. The case is presented of a 68-year-old male with skin rash, lymphadenopathy and hypereosinophilia who, after investigations, was diagnosed with AITL. Despite the treatment used, the patient's condition gradually deteriorated and died due to heart and kidney failure. The diagnosis of AITL is often established only after several weeks or months because of transient physical findings, non-specific symptoms, and a broad range of serologic or radiologic abnormalities. Some patients with AITL experience non-specific dermatitis and eosinophilia. The presented case should raise awareness of the presentations of AITL which is important for physicians to reach an accurate diagnosis.

show abstract

Section: Discussionmentioning

confidence: 73%

Fever, rash, and eosinophilia – early signs of angioimmunoblastic T-cell lymphoma

Wawrzycki

Prystupa

Szumiło

et al. 2021

Ann Agric Environ Med.

View full text Add to dashboard Cite

show abstract

“…Eosinophils are innate immune granulocytes derived from the bone marrow and are associated with helminthic infections, allergic diseases, and many inflammatory diseases (e.g., eosinophilic esophagitis, eosinophilic pneumonitis, and eosinophilic cellulitis) [106][107][108][109]. Eosinophils are recruited into sites of inflammation and release major basic protein, eosinophil cationic protein, eosinophil peroxide, eosinophil-derived neurotoxins, IL-4, IL-5, IL-13, and GM-CSF [14].…”

Section: Eosinophilsmentioning

confidence: 99%

The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome

Miyashiro¹,

Souza

Torrealba

et al. 2022

IJMS

View full text Add to dashboard Cite

Sézary syndrome is an aggressive leukemic variant of cutaneous T-cell lymphomas, characterized by erythroderma, lymphadenopathy, and peripheral blood involvement by CD4+ malignant T-cells. The pathogenesis of Sézary syndrome is not fully understood. However, the course of the disease is strongly influenced by the tumor microenvironment, which is altered by a combination of cytokines, chemokines, and growth factors. The crosstalk between malignant and reactive cells affects the immunologic response against tumor cells causing immune dysregulation. This review focuses on the interaction of malignant Sézary cells and the tumor microenvironment.

show abstract

“…ED is a heterogeneous group of cutaneous eruptions that predominantly occur in patients with indolent lymphoproliferative disorders, mainly CLL, in up to 6-8% of these cases [ 28 ]. Some patients, mainly those with acute leukemia, chronic myeloproliferative disorders, and plasma cell dyscrasias, may also present this dermatosis [ 29 ].…”

Section: Reviewmentioning

confidence: 99%

Immune-Mediated Cutaneous Paraneoplastic Syndromes Associated With Hematologic Malignancies: Skin as a Mirror of Hematologic Neoplasms

Álvarez-Payares¹,

Molina²,

Gallo³

et al. 2021

Cureus

View full text Add to dashboard Cite

Malignant neoplasms may present as paraneoplastic syndromes with mucocutaneous manifestations, which may or may not be chronologically associated. The pathophysiological mechanism is complex and not completely understood; therefore, definitive diagnosis may be achieved with a precise differential diagnosis based on the morphology of skin lesions, clinical picture, and histological pattern. The complexities, and low frequency, make the therapeutic approach quite challenging; consequently, the cornerstone of therapy is the eradication of the underlying neoplasms. Corticosteroids are the therapy of choice for most of these immune-mediated manifestations, but for the most part, the successful resolution requires the eradication of the underlying malignancy.

show abstract

Eosinophilic Dermatoses: Recognition and Management

Cited by 41 publications

References 147 publications

Fever, rash, and eosinophilia – early signs of angioimmunoblastic T-cell lymphoma

Fever, rash, and eosinophilia – early signs of angioimmunoblastic T-cell lymphoma

The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome

Immune-Mediated Cutaneous Paraneoplastic Syndromes Associated With Hematologic Malignancies: Skin as a Mirror of Hematologic Neoplasms

Contact Info

Product

Resources

About