Eosinophilic Esophagitis Associated with Celiac Disease in Children

Dharmaraj, Rajmohan; Hagglund, Karen; Lyons, Hernando

doi:10.1038/ajg.2013.272

Cited by 5 publications

(12 citation statements)

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“…Also, a correlation between three other identified syndromes, Hallermann-Strieff, Crouzon and 18q deletion, and CD was not found in the literature. The association between eosinophilic esophagitis (EoE) and CD remains controversial, with studies yielding different results (52,53) . We found a prevalence of EoE of 1.9% in our case series, but a prevalence ranging from 3.2% to 10% has been described (52,54,55) .…”

Section: Discussionmentioning

confidence: 99%

Review of Celiac Disease Presentation in a Pediatric Tertiary Centre

Oliveira¹,

Mohan

Fagbemi

2018

Arq. Gastroenterol.

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Section: Discussionmentioning

confidence: 99%

Review of Celiac Disease Presentation in a Pediatric Tertiary Centre

Oliveira¹,

Mohan

Fagbemi

2018

Arq. Gastroenterol.

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“…Similarly, Johnson et al 24 reported that EE was resolved after GFD in half of the adult patients with CD and EoE (n = 6). Although some reports suggested that increased mucosal permeability secondary to CD may lead to atopy because of increased exposure to antigens and allergens and causes EoE, 8,10,11 Leung et al 25 reported that an alteration in gastric and intestinal permeability does not play a role in EoE pathogenesis. According to molecular mechanisms Eotaxin‐3, interleukin‐5 and interleukin‐13 are reported to be the key effector molecules in EoE pathogenesis 7 …”

Section: Discussionmentioning

confidence: 99%

“…Although an association between CD and EoE has been reported in some studies, 8‐14 some researchers denied this relation 18‐20,29 . Hommeida et al 18 retrospectively reviewed 10.201 children who underwent endoscopic evaluation and found that the prevalence of EoE in children with CD was 1.83% when compared with 5.83% in all children who had EoE and stated that there was no increased risk of EoE in children with CD.…”

Section: Discussionmentioning

confidence: 99%

“…CD is a T‐helper cell‐1 (Th1)‐mediated, whereas EoE is T‐helper cell‐2 (Th2)‐mediated autoimmune disease 6,7 . It has been suggested that autoimmune and atopic diseases share risk factors that increase the propensity of the immune system to generate both Th1‐ and Th2‐mediated inappropriate responses to nonpathological antigens 6,8 …”

Section: Introductionmentioning

confidence: 99%

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Association of celiac disease with eosophageal eosinophilia and eosinophilic eosophagitis

Urgancı

Usta

Civelek

2021

Int J Clinical Practice

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Background Aim of the study was to evaluate the association between celiac disease and eosinophilic oesophagitis/oesophageal eosinophilia in children. Methods A total of 278 patients with celiac disease (mean age: 7.12 ± 4.64 years, M/F: 0.77) were involved in the study. The patients were evaluated retrospectively in terms of clinical, endoscopic and histopathological findings. The association between celiac disease and eosinophilic oesophagitis/oesophageal eosinophilia was determined. Results According to Marsh classification system 6 (2.1%) of the patients were graded type 3A, 10 (3.5%) were type 3B, 262 (94.4%) were type 3C. The histopathological examination of oesophageal biopsy specimens of the patients revealed <15 eosinophils per high power field in only 4 (1.4%) patients. Two of these patients were positive for HLA DQ8, one was DQ2, and the other one was both DQ8 and DQ2. Tissue transglutaminase IgA level was above 300 U/mL in these patients. None of them had elevated serum total IgE levels, peripheral eosinophilia and history of atopic diseases. The gastrointestinal symptoms resolved and tissue transglutaminase IgA level of the patients were declined after 3 months of gluten‐free diet. Conclusion Although an association between celiac disease and eosinophilic oesophagitis/oesophageal eosinophilia have been postulated in recent years, no exact relationship was established in this study. This is the first study reporting the performance of follow‐up GI endoscopy with biopsies revealing the resolution of oesophageal eosinophilia.

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“…Celiac disease is linked with EoE; [76][77][78][79][80] in fact, a diagnosis of celiac disease increases risk for EoE by at least 25%. 78 EoE and celiac disease share common features including that both are food antigen-driven, although there is limited evidence that gluten is a causal food in EoE, 81 both involve a pathophysiology that places epithelial cells in the center stage, and both resolve upon removal of causal foods.…”

Section: Eoe Is Associated With Celiac Disease But Not the Human Leukmentioning

confidence: 99%

Genetics of Eosinophilic Esophagitis

Rothenberg¹

2011

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Eosinophilic esophagitis (EoE) is a chronic, allergic disease associated with marked mucosal eosinophil accumulation. EoE disease risk is multifactorial and includes environmental and genetic factors. This review will focus on the contribution of genetic variation to EoE risk, as well as the experimental tools and statistical methodology used to identify EoE risk loci. Specific disease-risk loci that are shared between EoE and other allergic diseases (TSLP, LRRC32) or unique to EoE (CAPN14), as well as Mendellian Disorders associated with EoE, will be reviewed in the context of the insight that they provide into the molecular pathoetiology of EoE. We will also discuss the clinical opportunities that genetic analyses provide in the form of decision support tools, molecular diagnostics, and novel therapeutic approaches.

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Eosinophilic Esophagitis Associated with Celiac Disease in Children

Cited by 5 publications

References 0 publications

Review of Celiac Disease Presentation in a Pediatric Tertiary Centre

Review of Celiac Disease Presentation in a Pediatric Tertiary Centre

Association of celiac disease with eosophageal eosinophilia and eosinophilic eosophagitis

Genetics of Eosinophilic Esophagitis

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