Eosinophilic esophagitis: asthma of the esophagus?

Arora, Amindra S.; Yamazaki, Kiyoshi

doi:10.1016/s1542-3565(04)00236-8

Cited by 160 publications

(147 citation statements)

References 57 publications

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“…Its accelerated incidence, particularly in children and young men, may represent merely heightened recognition from increased medical publications and more frequent endoscopic procedures, but more likely is a true increase in disease burden [Prasad et al 2009]. This now well-recognized entity is found in up to 1% of the population [Furuta et al 2007;Gonsalves, 2007;Arora and Yamazaki, 2004]. EE is not characterized by features of either EG or EC.…”

Section: Eosinophilic Esophagitismentioning

confidence: 99%

Eosinophilic colitis: epidemiology, clinical features, and current management

Alfadda

Storr

Shaffer

2010

Therap Adv Gastroenterol

126

137

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Primary eosinophilic gastrointestinal disorders (EGIDs) represent a spectrum of inflammatory gastrointestinal disorders in which eosinophils infiltrate the gut in the absence of known causes for such tissue eosinophilia. EGIDs can be subgrouped as eosinophilic esophagitis (EE), eosinophilic gastroenteritis (EG), and eosinophilic colitis (EC). The least frequent manifestation of EGIDs is EC. EC is a heterogeneous entity with a bimodal age distribution, presenting with either an acute self-limited bloody diarrhea in otherwise healthy infants or as a more chronic relapsing colitis in young adults. The pathophysiology of primary EC appears related to altered hypersensitivity, principally as a food allergy in infants and T lymphocytemediated (i.e. non-IgE associated) in young adults. In adults, symptoms include diarrhea, abdominal pain, and weight loss. Endoscopic changes are generally modest, featuring edema and patchy granularity. Although standardized criteria are not yet established, the diagnosis of EC depends on histopathology that identifies an excess of eosinophils. Therapeutic approaches are based on case reports and small case series, as prospective randomized controlled trials are lacking. Eosinophilic colitis in infants is a rather benign, frequently food-related entity and dietary elimination of the aggressor often resolves the disorder within days. Adolescent or older patients require more aggressive medical management including: glucocorticoids, antihistamines, leukotriene receptors antagonists as well as novel approaches employing biologics that target interleukin-5 (IL-5) and IgE. This review article summarizes the current knowledge of EC, its epidemiology, clinical manifestations, diagnosis, and treatment.

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Section: Eosinophilic Esophagitismentioning

confidence: 99%

Eosinophilic colitis: epidemiology, clinical features, and current management

Alfadda

Storr

Shaffer

2010

Therap Adv Gastroenterol

126

137

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“…En este número de la revista Anales del Sistema Sanitario de Navarra se publica un trabajo sobre correlación de la inflamación esosinofílica bronquial y la medición de óxido nítrico en aire exhalado, otro sobre calidad de vida en la rinitis alérgica y una revisión de una serie de casos de esofagitis eosinofílica en adultos. Esta entidad, inicialmente descrita como una enfermedad predominantemente infantil, parece estar aumentando su incidencia tanto en niños como en adultos y ha sido comparada con el asma 21 , con quien parece compartir aspectos patogénicos. Las tres entidades, rinitis, asma y esofagitis eosinofílica rinden tributo al que, como dice la canción, "sigue siendo el rey".…”

Section: Be Garcíaunclassified

El esosinófilo: ¿"sigue siendo el rey"?

García

2009

Anales Sis San Navarra

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“…3 In the past few years, EE has been increasingly recognized as a distinct condition that affects about 1% of the population, and accounts for dysphagia and food impaction that remain nonresponsive to traditional anti-reflux management, both in pediatric and adult gastroenterology. 4 Accordingly, several excellent reviews on EE have recently been published. [4][5][6] In contrast, EC represents the least frequent manifestation of EGID whether or not it presents with disease in other segments of the gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

“…4 Accordingly, several excellent reviews on EE have recently been published. [4][5][6] In contrast, EC represents the least frequent manifestation of EGID whether or not it presents with disease in other segments of the gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Eosinophilic colitis in 36 years old female: a case presentation with review of literature

et al. 2015

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<p class="abstract"><span lang="EN-US">Eosinophilic Colitis (EC) is a rare form of primary eosinophilic gastrointestinal disease with prevalence in neonates and young adults. EC condition is less understood as compared to the recognized eosinophilic esophagitis. Clinically EC presents as highly variable disease and it is based according to mucosal, transmural, or serosal predominance of inflammation. EC has a vast range of differential diagnosis because eosinophilia of colon occurs in many conditions like parasitic infection, Inflammatory Bowel Disease (IBD), drug-induced allergic reactions and various connective tissue disorders and so it require to rule out these causes by thorough searching for secondary causes which can be treated with antibiotics or dietary and drug elimination before we start the EC treatment. EC responds very well to steroids that may be spared by using antihistamines, leukotriene inhibitors and biologics. Here we present a case of EC in a 36 years old female with pain in abdomen and bloody diarrhoea.</span></p>

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Eosinophilic esophagitis: asthma of the esophagus?

Cited by 160 publications

References 57 publications

Eosinophilic colitis: epidemiology, clinical features, and current management

Eosinophilic colitis: epidemiology, clinical features, and current management

El esosinófilo: ¿"sigue siendo el rey"?

Eosinophilic colitis in 36 years old female: a case presentation with review of literature

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