Eosinophilic folliculitis in a patient after allogeneic bone marrow transplantation: Case report and review of the literature

Abstract

We describe a patient with eosinophilic folliculitis (EF) that developed 3 months after allogeneic bone marrow transplantation (BMT) for chronic myelogenous leukemia. Skin biopsy specimen revealed numerous eosinophil infiltrations from the hair follicles to the sebaceous glands. No sign of skin graft-versus-host disease (GVHD) was found. The skin lesions and peripheral eosinophilia subsided within 5 weeks. In the following 8 months, the rash did not recur and GVHD has not developed. Taken together with previous reports, the present case demonstrates that it is important to recognize this distinct skin condition to avoid an inference that it may manifest itself as one of the signs of skin GVHD. Am.

Eosinophilic folliculitis following allogeneic peripheral blood stem cell transplantation: case report and review

“…Eosinophilic folliculitis has been associated with varying disorders since its first description 2 . In recent years, cases have been reported in patients subjected to hematological transplantation 4–9 . Of these cases, seven were autologous BMTs 4,6–9 and two cases were allogeneic transplantations 5,8 .…”

“…Because of these varying associations, it has come to be considered as a pattern of reaction related to diseases with immune dysregulation 3 . One example of these associations could be the cases of eosinophilic folliculitis appearing in patients following bone marrow transplantation (BMT), with an increasing number of reports in recent years 4–9 …”

Eosinophilic folliculitis in association with chronic lymphocytic leukemia: A clinicopathologic series

“…Additionally, the occurrence of EF after chemotherapy, bone marrow transplantation (BMT), or stem cell transplantation (SCT) is a commonly reported feature 1, 2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15Table IIClinicopathologic features of EF associated with underlying hematologic malignancy other than CLLStudyAge, ySexUnderlying hematologic malignancyTreatment for malignancyPeripheral eosinophiliaClinical descriptionDistributionNotable histologic featuresTakamura et al 6 77MMantle cell lymphomaChemotherapy13%Pruritic, erythematous papulesFace, neckEosinophils around follicles and sebaceous glandsTakamura et al 6 60MMantle cell lymphomaChemotherapy3.7%Pruritic, follicular reddish papulesFaceEosinophils around follicles and sebaceous glandsBhandare et al 8 64FSplenic marginal zone lymphomaChemotherapy2968/mL 3 Pruritic, follicular papules and pustulesScalp, back, proximal extremitiesFollicular spongiosis with eosinophilsZitelli et al 1 56MAcute lymphoblastic leukemiaAutologous SCT6.4%Pruritic papules and pustulesFace, chest, and backIntrafollicular collections of eosinophilsSugaya et al 9 42MSézary syndromeN/A9.5%Pruritic reddish follicular papulesCheeksProminent follicular exocytosis of eosinophilsRashid et al 10 74MChronic myelomonocytic leukemiaChemotherapyN/APruritic perifollicular papulesNeck and chestPerifollicular infiltrates with eosinophils, follicular mucinGoiriz et al 7 25FAcute eosinophilic leukemiaAllogene...…”

Eosinophilic pustular folliculitis in a patient with mycosis fungoides

“…In addition, EPF has been shown to be associated with bone marrow transplantation (BMT). 3 Here, we describe a case of EPF in a patient with mycosis fungoides (MF) who had received an unrelated BMT (uBMT).…”

“…plastic large cell lymphoma (ALCL), 3,4 acute myelogenous leukaemia (AML), B-cell chronic lymphatic leukaemia and acute lymphoblastic leukaemia (ALL) 3 have been reported. In addition, EPF has been shown to be associated with bone marrow transplantation (BMT).…”