Eosinophilic Granuloma Associated with Intratumoral Hemorrhage —Case Report—

Uranishi, Ryunosuke; Nikaido, Yuji; Eguchi, Takahiko; Bessho, Hironobu; Fujimoto, Takatoshi; Inui, Takuo

doi:10.2176/nmc.36.458

Cited by 3 publications

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“…12 Proliferation of endothelial cells within tumour vasculature leading to an occlusion or necrosis, tumour vessel fragility, and infiltration of tumour cells into the vessel walls are a proposed mechanism for intra-tumoral haemorrhage. 27 All patients with NTEDH due to EG had no other lesions or systemic disease and recovered fully.…”

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confidence: 90%

<p>Eosinophilic Granuloma of the Skull Presenting as Non-Traumatic Extradural Haematoma in Children</p>

Al-Mousa¹,

Al-Tarawneh

Alqatawneh

et al. 2020

IJGM

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Cranial extradural haematoma (EDH) is a neurosurgical emergency that can be caused by traumatic or non-traumatic causes with the former being more prevalent. Nontraumatic causes are variable and can include infection, vascular malformation and haematological disorders. This paper will address an extremely rare non-traumatic cause of EDH. More specifically, eosinophilic granuloma (EG), the localized form of Langerhans histiocytosis, may involve the skull and has rarely been reported to present with EDH. The case that will be presented is that of a three-year-old male patient, who presented with progressive vomiting and drowsiness, associated with left parietal swelling. CT scan of the brain showed an extradural haematoma and an osteolytic parietal lesion. He underwent emergent craniectomy, evacuation of the haematoma and dura resection as the lesion was infiltrating the dura. Histopathological examination of the dura and the bone edges showed eosinophilic granuloma (EG). The mechanism of a haemorrhage in this situation is poorly understood and the literature is extremely scarce. In conducting a thorough literature review, only 11 case reports of EG causing non-traumatic EDH were found. The details of these 11 cases will be reviewed and discussed in this paper, in addition to our illustrative case.

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confidence: 90%

<p>Eosinophilic Granuloma of the Skull Presenting as Non-Traumatic Extradural Haematoma in Children</p>

Al-Mousa¹,

Al-Tarawneh

Alqatawneh

et al. 2020

IJGM

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“…According to the literature, only one case of a parietal LCH lesion associated with bleeding components has been reported. [ 18 ] Furthermore, there are few reports about intracranial LCH presenting as an epidural hematoma or bleeding cyst. [ 5 11 12 13 18 ] In case of intratumoral hemorrhage, the bleeding could be related to vascular occlusion or necrosis due to endothelial cells proliferation, rupture of fragile tumoral vessels, disappearance or reduction of the supportive tissue surrounding the tumoral vessels, and infiltration of vessel walls.…”

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confidence: 99%

A rare case of solitary brain Langerhans cell histiocytosis with intratumoral hemorrhage in a patient affected by Turner syndrome

Granata¹,

Morabito²,

Grasso³

et al. 2016

Surg Neurol Int

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Background:Langerhans cell histiocytosis (LCH) is a rare disease involving clonal proliferation of cells with characteristics similar to bone marrow-derived Langerhans cells. The case of a young woman, affected by Turner syndrome and a solitary intraparenchymal LCH associated with an osteolytic lesion of the overlying skull, is presented.Case Description:The patient, with an insidious history of headache and a growing soft mass in the left frontal region, presented with a sudden generalized tonic-clonic epileptic seizure. Neuroradiological investigations showed an osteolytic lesion of the left frontal bone and an underlying brain lesion associated with recent signs of bleeding. The patient was operated on with a complete removal of the lesion. The postoperative course was uneventful.Conclusions:The clinical, neuroradiological, and intraoperative findings are presented, along with a review of the literature. Although rare, LCH should be considered in the differential diagnosis when a scalp lesion occurs with a progressive growing.

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Fluid-fluid levels in transcalvarial Langerhans? cell histiocytosis

Taranath

Onikul

2004

Pediatric Radiology

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Eosinophilic Granuloma Associated with Intratumoral Hemorrhage —Case Report—

Cited by 3 publications

References 0 publications

<p>Eosinophilic Granuloma of the Skull Presenting as Non-Traumatic Extradural Haematoma in Children</p>

<p>Eosinophilic Granuloma of the Skull Presenting as Non-Traumatic Extradural Haematoma in Children</p>

A rare case of solitary brain Langerhans cell histiocytosis with intratumoral hemorrhage in a patient affected by Turner syndrome

Fluid-fluid levels in transcalvarial Langerhans? cell histiocytosis

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