Eosinophilic granuloma of C4 causing spinal cord compression

Maggi, G; Sanctis, N. de; Aliberti, Ferdinando; Rega, A.

doi:10.1007/bf00261660

Cited by 12 publications

(17 citation statements)

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“…In 1953, Lichtenstein grouped three diseases under the denomination "histiocytosis X ": Hand-Schuller-Christian (HSC), Letterer-Siwe (LS) diseases and eosinophilic granuloma (EG), referring to the basic subjacent proliferation of histiocytes (Langerhans'cells) in all three conditions and to the unknown ethiology 2,[13][14][15][16] . On this occasion, they were already known as variations in extents, involvement stage and localization of the same basic disease of the reticuloendothelial system, with sharp differences both in prognosis and therapy 2,6,10,14 .…”

Section: Discussionmentioning

confidence: 99%

“…The term "eosinophilic granuloma" was coined by Lichtenstein and Jaffe in 1940 when they reported two cases of solitary lytic bone lesions consisting microscopically of clusters of phagocytic cells and significative collections of eosinophils 1,13,14 . There is considerable disagreement about the nature of the histiocytoses.…”

Section: Discussionmentioning

confidence: 99%

“…São Although it represents less than 1% of all primitive bone tumour 7,11 , it also corresponds to arround 75% of all the histiocytosis X that primarily attack adolescents and young adults with 80% of the cases occurring before the age of 10 years 8,9,[11][12][13] . The osteolytic lesion can occur in any skeleton's bone, with the vertebral body accounting for aproximately 80% of the cases.…”

mentioning

confidence: 99%

“…The osteolytic lesion can occur in any skeleton's bone, with the vertebral body accounting for aproximately 80% of the cases. Of this 54% are located in the thoracic region, 35% in the lumbar, and 11% in the cervical segment 12,13 . In adults the localization in the cervical region, associated to symptoms of spinal cord compression or myelorradiculopathy, is still rarer 9,12 .…”

mentioning

confidence: 99%

“…In adults the localization in the cervical region, associated to symptoms of spinal cord compression or myelorradiculopathy, is still rarer 9,12 . A review of the recent literature referable to these condition, related to the cervical localization disease, there were compiled only five cases with characteristics signs of spinal cord compression 3,4,8,12,13 . We are reporting an additional case of eosinophilic granuloma, the sixth to add to the literature, issuing a displacement of the spinal cervical cord and compression of the roots, whose diagnosis was established after the complete investigation and also by the lesion histopathology.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Cervical spine cord compression by eosinophilic granuloma: case report

Duarte-Silva

Noujaim

Carnevale

1999

Arq. Neuro-Psiquiatr.

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-Eosinophilic granuloma is a term reserved for the most often and benign form of disorder known as Langerhans cells histiocytosis. It is a disease of children and adolescents that very rarely affects adults, representing the localized form of a pathological proliferation of histiocytes in bones, like skull and long bones. Vertebral involvement is uncommon, approximately 8% of the cases, being the cervical localization the least affected. Moreover, the involvement of the spinal cord and roots remains a rare occurrence. Only five cases characterized by signs of cervical spinal cord compression have been reported. We report the sixth case in a 42-year-old-man who evolved with resolution of symptoms, and has remained asymptomatic after treatment. The clinical, radiological and histological features and, also, the value, in selected cases, of surgical treatment followed by low-dose radiation therapy is discussed. A review of the pertinent literature is also presented.KEY WORDS: cervical eosinophilic granuloma, cervical spinal cord compression, Langerhans cells histiocytosis. Compressão medular cervical por granuloma eosinofílico: relato de casoRESUMO -Granuloma eosinofílico é um termo reservado para a forma mais frequente e benigna da enfermidade conhecida como histiocitose das células de Langerhans. É uma doença de crianças e adolescentes, muito raramente afetando adultos, representando a forma localizada de uma proliferação patológica de histiócitos em ossos, crânio e ossos longos. O acometimento vertebral é incomum, aproximadamente 8% dos casos, sendo a localização cervical a menos descrita. Além disso, o acometimento da medula espinhal e das raízes é de rara ocorrência. Na literatura foram relatados apenas cinco casos caracterizados por sinais de compressão medular cervical. Relatamos o sexto caso, de um homem de 42 anos de idade que evoluiu com regressão dos sintomas após tratamento, tendo permanecido assintomático. As características clínicas, radiológicas, histopatológica e o valor, em casos selecionados, do tratamento cirúrgico seguido de radioterapia em baixas doses são discutidos. Revisão da literatura pertinente também é apresentada. PALAVRAS-CHAVE: granuloma eosinofílico cervical, compressão medular cervical, histiocitose das células de Langerhans.The term eosinophilic granuloma was introduced in 1940 by Jaffe and Lichtenstein 1 in order to describe an isolated bone tumour, and also to nominate the most benign form of histiocytosis X or, more recently 2 , Langerhans cells histiocytosis, which is a generic term that includes two uncommon diseases: Hand-Schuller-Christian and Letterer-Siwe diseases. Such pathological entities have in common a histopathological characteristic pattern of histiocytary nature (Langerhans cells) associated with eosinophils 1-10 .

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