Eosinophilic granuloma of spine in adults: a case report and review of literature

Abstract

A rare case of eosinophilic granuloma in an adult is reported. Eosinophilic granuloma (EG) is a lesion observed more frequently in adults. CT and MRI showed a lytic lesion of the T11 vertebral body. A transpedicular excisional biopsy of the lesion revealed EG. Spinal EG in adults is rare and differs from the childhood disease by the spinal level involvement. Vertebra plana, a condition of spondylitis in which the body of the vertebra is reduced to a sclerotic disc, is not a roentgenographic feature in the 14 cases reported in literature. It should be included in the differential diagnosis of the solitary lytic lesion of vertebrae in adults.

Signal Intensity Changes on MRI During the Healing Process of Spinal Langerhans Cell Granulomatosis

“…6,16 Several reports described the findings of MR images of spinal LCG; compared with the normal neighboring vertebrae, the tumor- like lesions showed low to iso signal intensities on T1WI, high intensity on T2WI, and uniformly or inhomogeneous or dense rim enhancement with Gd-DTPA, which might indicate that those lesions have tumorous potential or bone marrow edema. 6,7,17 In our case 1, which had unifocal LCG, 3 on T1WI, the tumor-like lesion first showed low signal intensity and changed to high intensity at 1 year. Its area had become smaller by then.…”

Sacral Spine Eosinophilic Granuloma in an Adult Patient: A Case Report of Unusual Age and Location

“…In general population, the thoracic vertebra are involved most often (54%) followed by lumbar (35%) and cervical (11%) spine (12,16). In adults, the cervical vertebra is most often involved (47%) spine bone followed by thoracic (33%) and lumbar (20%) vertebra (1,6). The rate of sacral vertebra involvement is not mentioned in literature.…”

“…Approximately 80% of cases occur in children younger than 10 years of age (3,4). Spine involvement has been found in approximately 7-15% of cases (5, 11) with a predilection for the cervical spine (47%), followed by the thoracic (33%) and lumbar (20%) spines in adults (6). Furthermore, there isn't any report on the frequency of sacral spine involvement in adults.…”

Solitary eosinophilic granuloma of the adult lumbar spine

“…Solitary EG of the spine involves differential diagnosis with osteoblastoma, aneurysmal bone cyst, Ewing's sarcoma, acute leukemia, Gaucher's disease and metastatic tumor [11]. Spondylitis can also be considered.…”