Eosinophilic granuloma of the mandibular condyle: Report of three cases and review of the literature

Solitary Eosinophilic Granuloma of Mandibular Condyle: Literature Review and Report of a Rare Case

“…Histiocytosis-X, recently termed Langerhans cell histiocytosis, is histologically characterized by an abnormal proliferation of histiocytes and usually a massive aggregation of eosinophilic leukocytes [12]. EG of bone has traditionally been included as one of the three clinical manifestations of the histiocytosis-X group of diseases, which also encompasses Hand-Schuller-Christian disease and Letterer-Siwe disease [13].…”

“…Eosinophilic granuloma of bone, or chronic localized LCH, occurs primarily in children and young adults, with the highest incidence in the first decade of life [12,13]. Men are affected twice as much as women.…”

“…Although radionuclide [1]. Positive immunostaining for S-100 protein and CDla antigen can help distinguish LCH from other histiocytic lesions [12,17]. As the lesion matures, fibrosis occurs, with a reduction of the histiocytic and eosinophilic component and with gradual replacement by nests of granular to foamy macrophages.…”

“…It can affect almost any bone and commonly involves the mandible when the jaws are affected. It is usually managed empirically with surgery, radiotherapy, chemotherapy, and intralesional steroid injection, because its etiology remains mainly unknown [12]. We report a rare case of solitary EG involving mandibular condyle in a 49-year-old male patient which is the first of its kind in Indian literature.…”

“…It is characterized by a rapidly progressive course with widespread multiple organ system involvement and a usually fatal clinical course in infants. Skeletal lesions of LCH have been well documented, especially in the skull, facial bones, long bones, pelvis, vertebrae, and ribs [11,12]. In the mandible, lesions occur more commonly in the body, followed by the ramus.…”