Eosinophilic granuloma with involvement of the female genitalia

Issa, Philip; Salem, Philip A.; Brihi, Emile; Azoury, Ramez S.

doi:10.1016/0002-9378(80)90705-x

Cited by 26 publications

(8 citation statements)

References 11 publications

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“…Primary pulmonary EG is a well-defined extra-osseous entity (Basset et al, 1978;. EG has also been reported in the larynx (Friedman & Ferlito, 1981), in the female genitalia (McKay et al, 1953;Issa et al, 1980), in the cutis (Rodman & Cooper, 1980), hypothalamus and cerebrum (Keppes & Keppes, 1968;Tibbs et al, 1978;Smolik et al, 1968) and other organs.…”

Section: Discussionmentioning

confidence: 93%

Solitary eosinophilic granuloma of sternum: case report with review of the literature

Peer¹,

Witz²,

Yona³

et al. 1985

BJR

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A solitary lesion in the distal sternum in a 30-year-old woman caused by eosinophilic granuloma (EG) is reported. Bone scan with 99Tcm was negative. Laboratory tests were completely normal. Although EG bone lesions have been discussed extensively in the literature only one similar case of solitary EG of the sternum has been published to date. A comprehensive summary of the literature is presented.

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Section: Discussionmentioning

confidence: 93%

Solitary eosinophilic granuloma of sternum: case report with review of the literature

Peer¹,

Witz²,

Yona³

et al. 1985

BJR

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“…To date, there have been 54 published cases of LCH of the genital tract, 12 of which involve isolated lesions without other organ involvement (Table 2) (5,8,(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45) . Genital LCH can present as pruritic erythematous lesions, resembling eczema, or as erythematous papules.…”

Section: Clinical Aspectsmentioning

confidence: 99%

Langerhans cell histiocytosis of the female genital tract: A literature review

MONTERO,

DÍAZ-MONTERO,

MALPICA

et al. 2003

Int J Gynecol Cancer

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Langerhans cell histiocytosis (LCH) is a rare malignant disease involving the accumulation of a monoclonal proliferation of cells in various organs, that phenotypically resemble Langerhans cells (LC). LCH is not merely a hyperplasia of LC, as it typically affects organs that are outside of their normal physiologic distribution. Normal Langerhans cells are bone marrow-derived dendritic cells that populate the epidermis and are distinguished by the presence of Birbeck granules and cell surface protein CD1a. LC act as sentinels; they recognize, internalize, and process antigens encountered in the skin. Upon encountering an antigen, LC become activated with subsequent maturation and induction of their migratory capacity. Langerhans cells in patients with LCH are aberrant and profoundly differ from normal LC. The clinical spectrum of LCH is quite diverse; multiple organs can be affected. “Pure” genital Langerhans cell histiocytosis is a rare presentation, with only 12 previously reported cases. Due to the rarity of this disease, treatment of genital LCH is still very diverse. No modality is proven to be superior in improving patient outcome, and relapses frequently occur after surgery. Dramatic responses of cutaneous and ano-genital lesions to thalidomide and interferons have been reported. We advocate the use of immuno-modulating agents in LCH of the female genital tract first, rather than surgery.

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“…To the Editor: 5-FU, a potent antimetabolic analogue of thymine, has been demonstrated to be fairly succesful in the treatment of gastro-enteric tumors and carcinoma of the breast. Systemic administration of this drug may induce various skin changes including inflammation due to actinic keratosis [1-3], exacerbation of seborrheic dermatitis [4] resembling sometimes lupus erythematosus [1,5], folliculitis eruptions on the forehead [3,6], maculopapular eruption on the palms [7], palmar keratoderma [8]. Another side effect described in the last few years [9][10][11] is palmar-plantar erythrodysesthesia (PPE).…”

Section: -Fluorouracil-associated Hyperpigmentationmentioning

confidence: 99%

“…However, the most common type of fluorouracilassociated dermatitis is a photo-mediated form which includes erythema and, above all, hyperpigmentation. In such cases "supraveonous hyperpigmentation" is connected with the veins used for 5-FU infusion and the hyperpigmentation assumes a serpiginous appearance [3.12], In other cases the hyperpigmentation may be localized on the dorsa of the hands present in stripes or small spots, or be confined the skin covering the metatarsophalangeal joints [7]; lesions may also be found on the soles and, occasionally, the trunk, nails [6] and oral mucosa [H].…”

Section: -Fluorouracil-associated Hyperpigmentationmentioning

confidence: 99%

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Langerhans cell histiocytosis of the vulva

Fuente

Bielsa

Fernandez

et al. 1996

Acad Dermatol Venereol

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Langerhans cell histiocytosis of the vulvaTo the Editor: Langerhans cell histiocytosis (LCH) is regarded as a functional disorder of immune regulation that results in the proliferation of itnmature Langerhans cells [l]. The disorder may be localized or disseminated with multisystemic disease. The oral cavity is frequently affected, but the involvement of the female genital tract is very uncommon [l]. We describe two patients who had LCH of the genital tract.Case 7. A 38 year-old woman, in previously good health, presented in 1987 a bilateral pneumothorax.The chest X-ray demonstrated a honeycombed reticulonodular pattern, and a lung biopsy was compatible with pulmonary histiocytosis X. One year later, she developed poiyuria and polydipsia and the diagnosis of diabetes insipidus was made. In 1989, two osteolytic lesions were detected by bone X-ray in the palate and the mandible, respectively. Six months later, she noticed the appearance of ptiiritic ulcerative lesions on the right axilla and vulva. Cutaneous physical examination revealed two indurated ulcers with undermined borders, 1 cm in size, localized on the right labium minora of the vulva and the right axilla. Histological, ultrastructural and immunohistochemical ( Fig. 1) examination of biopsies taken frotn these lesions confirmed the diagnosis of LCH.Case 2. A 42 year-old woman had a six months history of pruritic, erosive and ulcerating lesions on the vulva. There was no significant past medical history. Physical examination revealed several small erosions over an erythematous area on the left labium minora. She was first treated with topical acyclovir and topical antibiotics without relief. The histological examination showed a dermal infiltrate containing abundant Langerhans-type histiocytes. Ultrastructural studies revealed the presence of Birbeck granules in the cytoplasm of these cells (Fig. 2). Extensive studies, including haematologic profile, serum and urine biochemistries, thyroid hormones and bone x-ray, were strictly normal and gave no evidence of multisystemic involvement. The lesions were treated with surgery, but a short time afterward she had a local recurrence. Three years later, she has developed poiyuria and polydipsia, and the diagnosis of diabetes insipidus has been made.

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Eosinophilic granuloma with involvement of the female genitalia

Cited by 26 publications

References 11 publications

Solitary eosinophilic granuloma of sternum: case report with review of the literature

Solitary eosinophilic granuloma of sternum: case report with review of the literature

Langerhans cell histiocytosis of the female genital tract: A literature review

Langerhans cell histiocytosis of the vulva

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