Eosinophilic infiltrates of the gastrointestinal tract.

Blackshaw, A.J.; Levison, D. A.

doi:10.1136/jcp.39.1.1

Cited by 177 publications

(87 citation statements)

References 28 publications

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“…A few recent studies also revealed a relation between IFP and H. pylori infection but an infective ethiology has never been reported yet [11]. In one of these reports, the patient also had an autoimmune diseases (sarcoidosis, rheumatoid arthritis, and ankylosing spondylitis) [15]. This finding supports the possibility of an immunological reaction as a contributing factor.…”

Section: Discussionsupporting

confidence: 73%

A Rare Combination of Gastric Inflammatory Fibroid Polyp and Hiatal Hernia

Polat¹,

Yazıcıoğlu²,

Türel³

et al. 2011

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Inflammatory fibroid polyp (IFP) is a rare solitary gastrointestinal lesion of unknown etiology. It generally presents as polypoid mass in the gastric antrum. Mostly affects adults at average age of 60 years. IFP can cause different symptoms such as abdominal pain, gastrointestinal bleeding, intestinal obstruction or intussusception. IFP is a bening lesion and it may rarely mimic the submucosal tumor. The diagnosis can be possible after removal of the detected lession either by laparoscopic or open approach. In the present paper, we report a patient with gastric IFP and hiatal hernia. IFP was excised throughout the gastrotomy and following hiatal hernia was repaired. According to our best knowledge, this may be the first case report of gastric IFP concomitance with a hiatal hernia.

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Section: Discussionsupporting

confidence: 73%

A Rare Combination of Gastric Inflammatory Fibroid Polyp and Hiatal Hernia

Polat¹,

Yazıcıoğlu²,

Türel³

et al. 2011

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“…In the healthy colon, eosinophil counts range from 5 up to 35 per high-powered field, with a proximal to distal gradient along the colon [Lowichik and Weinberg, 1996]. Hence, the diagnosis is contingent upon histological evidence of excessive [Blackshaw and Levison, 1986;Spry, 1984;Cello, 1979;Klein et al 1970] Eosinophilic proctocolitis (allergic proctocolitis or milk-protein proctocolitis) is an entity that has been described classically in infants associated with ingestion of cow's milk and soy proteins [Lake, 2000;Raafat et al 1990]. Thus, a bimodal age distribution of EC is apparent: an infantile form presenting at 60 days and an adolescent form later in life [Odze et al 1995].…”

Section: Eosinophilic Esophagitismentioning

confidence: 99%

Eosinophilic colitis: epidemiology, clinical features, and current management

Alfadda

Storr

Shaffer

2010

Therap Adv Gastroenterol

126

137

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Primary eosinophilic gastrointestinal disorders (EGIDs) represent a spectrum of inflammatory gastrointestinal disorders in which eosinophils infiltrate the gut in the absence of known causes for such tissue eosinophilia. EGIDs can be subgrouped as eosinophilic esophagitis (EE), eosinophilic gastroenteritis (EG), and eosinophilic colitis (EC). The least frequent manifestation of EGIDs is EC. EC is a heterogeneous entity with a bimodal age distribution, presenting with either an acute self-limited bloody diarrhea in otherwise healthy infants or as a more chronic relapsing colitis in young adults. The pathophysiology of primary EC appears related to altered hypersensitivity, principally as a food allergy in infants and T lymphocytemediated (i.e. non-IgE associated) in young adults. In adults, symptoms include diarrhea, abdominal pain, and weight loss. Endoscopic changes are generally modest, featuring edema and patchy granularity. Although standardized criteria are not yet established, the diagnosis of EC depends on histopathology that identifies an excess of eosinophils. Therapeutic approaches are based on case reports and small case series, as prospective randomized controlled trials are lacking. Eosinophilic colitis in infants is a rather benign, frequently food-related entity and dietary elimination of the aggressor often resolves the disorder within days. Adolescent or older patients require more aggressive medical management including: glucocorticoids, antihistamines, leukotriene receptors antagonists as well as novel approaches employing biologics that target interleukin-5 (IL-5) and IgE. This review article summarizes the current knowledge of EC, its epidemiology, clinical manifestations, diagnosis, and treatment.

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“…However, perivascular spindle cell arrangement is more common in IFP and eosinophil infiltration is more prominent (8). Furthermore, it is more common in the stomach and very rare in the colon (9). However, the reporters of the case series, including Eslami-Varzaneh, point to some similarities between IFP and BFPC and admit that the lesion may represent an early stage of the disease (1-4).…”

Section: Discussionmentioning

confidence: 97%