Eosinophilic Meningitis in a Case of Disseminated Glioblastoma

Defendini, Richard; Hunter, Stephen B.; Schlesinger, Edward B.; Leifer, Edgar; Rowland, Lewis P.

doi:10.1001/archneur.1981.00510010078016

Cited by 19 publications

(8 citation statements)

References 10 publications

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“…Reactive CSF eosinophilia has also been detected in T-lineage non-Hodgkin's lymphoma (99). Other malignancies that may involve CSF eosinophilia are disseminated glioblastoma (71) and carcinomatosis (62).…”

Section: Neoplastic Diseasesmentioning

confidence: 99%

Update on Eosinophilic Meningoencephalitis and Its Clinical Relevance

2009

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SUMMARY Eosinophilic meningoencephalitis is caused by a variety of helminthic infections. These worm-specific infections are named after the causative worm genera, the most common being angiostrongyliasis, gnathostomiasis, toxocariasis, cysticercosis, schistosomiasis, baylisascariasis, and paragonimiasis. Worm parasites enter an organism through ingestion of contaminated water or an intermediate host and can eventually affect the central nervous system (CNS). These infections are potentially serious events leading to sequelae or death, and diagnosis depends on currently limited molecular methods. Identification of parasites in fluids and tissues is rarely possible, while images and clinical examinations do not lead to a definitive diagnosis. Treatment usually requires the concomitant administration of corticoids and anthelminthic drugs, yet new compounds and their extensive and detailed clinical evaluation are much needed. Eosinophilia in fluids may be detected in other infectious and noninfectious conditions, such as neoplastic disease, drug use, and prosthesis reactions. Thus, distinctive identification of eosinophils in fluids is a necessary component in the etiologic diagnosis of CNS infections.

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Section: Neoplastic Diseasesmentioning

confidence: 99%

Update on Eosinophilic Meningoencephalitis and Its Clinical Relevance

2009

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“…4 Other parasites have been repor ted to be associated w i t h the disease including Hypoderma, 5 Gnathostoma, 6 Dirofilaria, 7 Toxocara 8 and Cysticerca 9 species. Central nervous system neoplasia (Hodgkin's disease, 10 leptomeningeal carcinomatosis, 11 acute lymphoblastic leukaemia, 12 glioblastoma 13 ), drug therapy (ibuprofen, 14 ciprofloxacin 15 ), infectious diseases (Rocky Mountain spotted fever, 16 cryptococcosis, 17 group B streptococcus, 18 coccidioidomycosis, 19 toxoplasmosis 20 ), cranial trauma, 21 myelography 22 and hypereosinophilic syndrome 23 have also been implicated in people. Naturally occurring cases have been rarely reported in the veterinary literature.…”

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confidence: 99%

Idiopathic eosinophilic meningoencephalitis in Rottweiler dogs: three cases (1992–1997)

et al. 1997

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“…Some of these cases present a definite eosinophilic meningeal infiltration which justifies neurological symptomatology. This way of involvement has been described in relation to some infectious diseases such as helminthiasis and more rarely Coccidioidis immitis is, meningitis by lymphomas 14,16 a nd in one case of disseminated glioblastoma 6 . On the contray sometimes hypereosinophilic syndrome may be accompanied by neu rological symptoms and eosinophilic pleocytosis in the CSF with pathological studies not revealing meningeal or parenchymatous infiltration 25.…”

Section: Commentsmentioning

confidence: 80%

Chronic pachymeningitis associated to hypereosinophilia: case report

Correale

Ameriso

Meli³

et al. 1988

Arq. Neuro-Psiquiatr.

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A male 22 years old patient who consulted due to headache and increasing visual loss is being presented. Alterations in the exam were represented by right amaurosis and left temporal hemianopsis. Pathological and tomographical studies revealed chronic pachymeningitis with eosinophilic infiltration. An elevated eosinophilia and an increasing in anti-A and anti-B isoagglutinins were associated to the clinical course. They returned to normal values after treatment with tiabendazol. Even though there is not a certain conclusion as regards the etiology, the probable parasitary nature of the process is outlined.

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Eosinophilic Meningitis in a Case of Disseminated Glioblastoma

Cited by 19 publications

References 10 publications

Update on Eosinophilic Meningoencephalitis and Its Clinical Relevance

Update on Eosinophilic Meningoencephalitis and Its Clinical Relevance

Idiopathic eosinophilic meningoencephalitis in Rottweiler dogs: three cases (1992–1997)

Chronic pachymeningitis associated to hypereosinophilia: case report

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