Eosinophilic otitis media; state-of-the-art diagnosis and treatment

Iino, Yukiko

doi:10.1016/j.anl.2022.11.004

Cited by 12 publications

(1 citation statement)

References 58 publications

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“…Eosinophilic otitis media (EOM) is a clinical condition presented by Iino et al (35,36). It comprises patients who fulfill one major criterion of either OME or COM with cytological or histological eosinophil predominance in MEE or middle ear tissue and at least two minor criteria of the following: highly viscous MEE, resistance to conventional OME therapy, association with bronchial asthma, and association with nasal polyposis.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Cytokines in Middle Ear Effusion of Patients With Asthma, Chronic Rhinosinusitis With Nasal Polyps With or Without NSAID Intolerance

Suikkila,

Lyly,

Savinko

et al. 2024

Otol Neurotol

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Objective To measure the inflammatory cytokines of middle ear effusion (MEE) in otitis media (OM) associated with asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) with or without nonsteroidal anti-inflammatory drug (NSAID) sensitivity to strengthen our assumption that OM is part of the same inflammatory entity. The potential individual differences between MEE inflammatory cytokines could be used in clinical practice for more individual characterization of the inflammation. Study Design Case-control study. Setting Tertiary referral center Patients Convenience sample of 24 case patients with otitis media with effusion (OME) or chronic otitis media (COM), asthma, and CRSwNP, 14 of whom had NSAID intolerance, and 8 controls with OME but no history of asthma, CRSwNP, or NSAID intolerance. Intervention Diagnostic Main Outcome and Measure Inflammatory cytokines including interleukins (IL)-4, IL-5, IL-6, IL-13, and interferon gamma (IFN-γ) in middle ear effusion. Results The MEE mass fractions of IL-5 (p = 0.003) and IFN-γ (p = 0.048) were higher among our case patients with OME/COM than among the controls. For IL-4 and IL-13, the mass fractions were also higher among the case patients than the controls, but this difference was not statistically significant (p = 0.199 and p = 0.617, respectively). We found no difference between the IL-6 mass fractions of the groups. We found notable heterogeneity in individual patients' cytokine levels. Conclusions According to our findings, OM, when present, should be considered part of the respiratory inflammatory process associated with asthma and CRSwNP. The individual differences in MEE cytokine levels could be useful as biomarkers.

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Section: Discussionmentioning

confidence: 99%