Eosinophilic Panniculitis Associated With COVID-19

Leis-Dosil, V.M.; Vicente, A.; Lorido-Cortés, M M

doi:10.1016/j.adengl.2020.10.003

Cited by 9 publications

(6 citation statements)

References 10 publications

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“…Enhanced TGF-b responses, mast cell activation, and more prompt and robust viral antigen-specific antibody responses strongly support the potential pathogenic role of eosinophil-mediated inflammation and Th2-biased mucosal immunity in critical COVID-19 (Figure 3G) (Lucas et al, 2020). Several studies have recently reported an association of systemic eosinophil-mediated inflammation with various COVID-19-associated syndromes (Craver et al, 2020;Leis-Dosil et al, 2020). It is also notable that the levels of ECP in respiratory specimens from critical elderly patients are significantly higher than those from younger patients, suggesting a potential role of aging-associated inflammation in critical .…”

Section: Discussionmentioning

confidence: 63%

Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19

Kim¹,

Kim²,

Seo³

et al. 2021

Cell Reports

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Despite the worldwide effect of the Coronavirus disease 2019 (COVID-19) pandemic, the underlying mechanisms of fatal viral pneumonia remain elusive. Here, we show that critical COVID-19 is associated with enhanced eosinophil-mediated inflammation when compared to non-critical cases. In addition, we confirm increased Th2-biased adaptive immune responses, accompanying overt complement activation, in the critical group. Moreover, enhanced antibody responses and complement activation is associated with disease pathogenesis as evidenced by formation of immune complexes and membrane attack complexes in airways and vasculature of lung biopsies from six fatal cases, as well as by enhanced hallmark gene set signatures of FcγR signaling and complement activation in myeloid cells of respiratory specimens from critical COVID-19 patients. These results suggest that SARS-CoV-2 infection may drive specific innate immune responses, including eosinophil-mediated inflammation, and subsequent pulmonary pathogenesis via enhanced Th2-biased immune responses, which might be crucial drivers of critical disease in COVID-19 patients.

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Section: Discussionmentioning

confidence: 63%

Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19

Kim¹,

Kim²,

Seo³

et al. 2021

Cell Reports

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“…7A, 7B). This was probably due to the aging-associated inflammation in the COVID-19 infection (Craver et al, 2020; Leis-Dosil et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Ultracellular Imaging of Bronchoalveolar Lavage from Young COVID-19 Patients with Comorbidities Showed Greater SARS-COV-2 Infection but Lesser Ultrastructural Damage Than the Older Patients

Chaudhary

Rai²,

Joshi³

et al. 2022

Microscopy and Microanalysis

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In this study, we examined the cellular infectivity and ultrastructural changes due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the various cells of bronchoalveolar fluid (BALF) from intubated patients of different age groups (≥60 years and <60 years) and with common comorbidities such as diabetes, liver and kidney diseases, and malignancies. BALF of 79 patients (38 cases >60 and 41 cases <60 years) were studied by light microscopy, immunofluorescence, scanning, and transmission electron microscopy to evaluate the ultrastructural changes in the ciliated epithelium, type II pneumocytes, macrophages, neutrophils, eosinophils, lymphocytes, and anucleated granulocytes. This study demonstrated relatively a greater infection and better preservation of subcellular structures in these cells from BALF of younger patients (<60 years compared with the older patients (≥60 years). The different cells of BALF from the patients without comorbidities showed higher viral load compared with the patients with comorbidities. Diabetic patients showed maximum ultrastructural damage in BALF cells in the comorbid group. This study highlights the comparative effect of SARS-CoV-2 infection on the different airway and inflammatory cells of BALF at the subcellular levels among older and younger patients and in patients with comorbid conditions.

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“…3 The pathophysiology of EP is related to the excessive production of cytokines, specifically IL-4 and IL-5, in response to various stimuli. 4 Covid-19 seems to be one of these stimuli, as there is a reported case of EP secondarily to Covid-19 infection. 4 Comparing our case of postvaccination EP with the reported post-Covid-19 EP, a similarity was found in patient characteristics (young women), time of onset of the lesions (around 20 days), predominant topography in the lower limbs and number of lesions.…”

mentioning

confidence: 98%

“…4 Covid-19 seems to be one of these stimuli, as there is a reported case of EP secondarily to Covid-19 infection. 4 Comparing our case of postvaccination EP with the reported post-Covid-19 EP, a similarity was found in patient characteristics (young women), time of onset of the lesions (around 20 days), predominant topography in the lower limbs and number of lesions. Similarities were not only clinical but also histological.…”

mentioning

confidence: 98%

Eosinophilic panniculitis: a new side effect of Sinopharm COVID‐19 vaccine

Kaikati

Abi‐Ghanem

Bahtimi³

et al. 2022

Acad Dermatol Venereol

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partial resolution of the infection is highly in favour of the association with the vaccine. Moreover, what happened in our patient is quite similar to the so-called BOTE (beginning of the end) sign, that is, the spontaneous erythematous-nodular reaction developing in the context of MC, just preceding and predicting the spontaneous resolution of MC itself. 9 Similar reactions have been noticed also in patients treated with potassium hydroxide. 10 The reasons of the secondary effect of COVID vaccine on MC are rather obvious, as the strong immune response induced by the vaccination could lead to a positive non-specific response also directed against another viral condition, such as MC.However, no previous reports about any similar reaction have been described in literature with any other vaccine. Two different explanations could be given to this apparent contradiction. The first may be related to the casual appearance of a BOTE sign in our patient unrelated to the administered vaccine. The second reason may be due to the scarce and underestimated observation of a similar reaction.Apart the first observation of a reaction against MC induced by COVID vaccine, our report is also the first positive reaction after vaccine. We hope that our description could be useful to researchers and clinicians as guidance for detection of similar reactions, to understand which could be the mechanisms laying under this fascinating phenomenon.

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Eosinophilic Panniculitis Associated With COVID-19

Cited by 9 publications

References 10 publications

Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19

Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19

Ultracellular Imaging of Bronchoalveolar Lavage from Young COVID-19 Patients with Comorbidities Showed Greater SARS-COV-2 Infection but Lesser Ultrastructural Damage Than the Older Patients

Eosinophilic panniculitis: a new side effect of Sinopharm COVID‐19 vaccine

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