Eosinophilic Proctitis with Giant Cells

Eosinophilic colitis: an update on pathophysiology and treatment

“…Eosinophilic proctocolitis (milk-protein proctocolitis) is an entity that has been described classically in infants associated with ingestion of soy protein and cow's milk. 46,47 It too has a bimodal age distribution: an infantile form presenting at 2 months and an adolescent form mimicking ulcerative colitis. 48 Infants typically have normal to soft stools with blood-streaks that arises during the first 2-3 months of age.…”

“…Elimination, oligoantigenic and elemental (amino-acid based) diets can provide symptomatic relief in many patients with EC, particularly infants with proctitis. 40,47 This strategy seeks to either eliminate certain food allergens that precipitate flares of EC or use a purely elemental diet containing simplified ingredients that are readily assimilated without further digestion (amino acids, hydrolyzed fats and carbohydrates). Such a diet can be effective in some instances but its poor palatability commonly diminishes compliance.…”

Food‐Induced Eosinophilic Proctocolitis

“…The eosinophils are frequently in association with lymphoid nodules, surrounding and penetrating the outer rim of the lymphoid aggregates (11). Granulomas are not seen, but giant cells have been reported (12).…”

The Polymorph in Red Is No Lady

“…Infants with allergic colitis are clinically distinguished by the generalization: Aside from the dirty diaper, the infant is well. Onset is nearly alway s in the first 4 months , averaging at 4 weeks of age (2)(3)(4)(5)(6)(7)(8)(9). Mild to moderate diarrhea grossly streaked with blood is the con sistent feature.…”