Eosinophilic Pustular Folliculitis

Abstract

Classical eosinophilic pustular folliculitis, or Ofuji's disease, is a chronic and relapsing dermatosis that is predominantly reported in East Asian populations. Clinically, the disease typically begins as small papules, which enlarge and coalesce into a large plaque, usually on the face. The histopathology is characterized by a prominent eosinophilic infiltrate in the dermis with concentration around pilosebaceous units, often with eosinophilic microabscess formation. The differentiation of eosinophilic pustular folliculitis from other eosinophilic dermatoses is practically challenging and requires close clinicopathologic correlation. Eosinophilic pustular folliculitis may also be associated with human immunodeficiency virus infection, various drugs, and some lymphomas and could also be thought of as a nonspecific dermatopathologic pattern in such settings. The cause of classical eosinophilic pustular folliculitis is unknown, although immune processes are almost certain to play a key role in its pathogenesis.

An occurrence of eosinophilic folliculitis and alopecia associated with a sustained complete response to mogamulizumab in Sézary syndrome: a case report

“… 16 – 18 EF diagnosed in this patient was associated with immunosuppression with a non-infectious inflammation of the pilosebaceous follicles that falls within a clinically and histologically heterogeneous group of skin conditions known as eosinophilic dermatoses. 22 – 25 These eosinophilic skin disorders arise from immune activation mediated by the overproduction of interleukin-5, which is involved in chemotaxis, maturation, and survival of eosinophils. 23 , 26 Upon activation, eosinophils release inflammatory proteins, including cationic proteins (major basic protein, eosinophil cationic protein, and eosinophil peroxidase).…”

Review of Peripheral Blood Eosinophilia: Workup and Differential Diagnosis

“…Eosinophilic pustular folliculitis (EPF) is a chronic, relapsing dermatosis primarily of patients of East Asian descent [24]. It is characterized by pruritic, follicular papulopustules with a predilection for seborrheic areas which are relapsing and remitting, sometimes leaving residual hyperpigmentation [24]. The disease is more often found in males by a ratio of 5:1 [24].…”

Infantile Eosinophilic Pustular Folliculitis in a Child Aged 7 Years: A Case Report

“…Histopathologically, inflammatory cells (mainly eosinophils) infiltrate the dermis and sebaceous glands of hair follicles and are usually associated with the formation of eosinophilic microabscesses. 3 …”

“…Histopathologically, inflammatory cells (mainly eosinophils) infiltrate the dermis and sebaceous glands of hair follicles and are usually associated with the formation of eosinophilic microabscesses. 3 Five cases of infantile EPF (I-EPF) were first reported in 1984 in children aged below 1 year. 4 However, it does not just occur in infants.…”