Eosinophilic pustular folliculitis.

A 75-year-old male with eosinophilic pustulosis Ofuji complicated by superinfection with Pseudomonas aeruginosa and Proteus mirabilis is described. This is the first case of eosinophilic pustulosis with an antiepidermal antibody. This antibody was directed against the intercellular substance of the lower epidermis and it was detected by direct immunofluorescence in the patient’s normal and lesional skin. As revealed by indirect immunofluorescence the patient’s serum reacted with intercellular substance of human lower epidermis but not with guinea pig esophagus. Possibly the detected autoantibody is not characteristic for eosinophilic pustulosis Ofuji but rather an accompanying feature of this case similar to the antiepidermal antibodies found in patients with drug reactions and burns.

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Eosinophilic Pustulosis with Pemphigus-Like Antibody

Vakilzadeh¹,

Suter²,

Knop³

et al. 1981

“…To our knowledge, more than 200 cases of EPF have been reported in Japan. There are also sporadic reports from other countries [2][3][4][5][6][7]. It usually starts as grouped pruritic follicular papulopus tules on the face and back.…”

mentioning

confidence: 99%

Eosinophilic Pustular Folliculitis Starting Initially only with Palmoplantar Pustular Lesions

Aoyama

Tagami

1992

We report a 23-year-old Japanese male with eosinophilic pustular folliculitis (EPF) that had started with palmoplantar rash. Only when follicular pustules appeared on the bilateral cheek 31 months later, we revised our initial diagnosis of pustulosis palmaris et plantaris (PPP) to EPF, and all the skin eruptions cleared mostly with indomethacin. A review of the Japanese literature for the past 20 years disclosed that in 207 cases of EPF so far reported, palmoplantar pustular lesion was noted in 38 (18%). Among them, in 16 cases (8%) the skin lesions started first from the palmoplantar region with the average period of 26 months until the appearance of other eruptions of EPF. None of them was diagnosed as EPF when skin lesions were localized only to the palmoplantar region. When we find pustules on the palmoplantar region, we should suspect the possibility of early lesions of EPF as well as PPP. Histopathologic demonstration of multilocular pustules located in the upper epidermis containing numerous eosinophils in the palmoplantar pustular lesions, together with the dramatic therapeutic response to indomethacin greatly favor the diagnosis of EPF.

“…Eosinophilic folliculitis (Ofuji's disease) is a disorder of unknown etiology that has been described mainly in Japan [11,12] although there have been some reports from Europe [13][14][15] or Spain [16,17] and recently from the United States [18][19][20]. It presents as papules and pustules centered by a hair folli cle that spread along its periphery.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Pustulosis: A Case Report

Barnadas

Moreno²,

Moragas³

1988

A 16-year-old female had a chronic cutaneous eruption clinically characterized by papules, pustules and large exudating plaques of 2 years duration. Multiple biopsies showed infiltration of the follicular epithelium by eosinophils and intraepidermal pustules with neutrophils and eosinophils that were accompanied either by acantholysis or spongiosis. Eosinophilia and hypoproteinemia were detected. A definite infectious etiology or autoimmune mechanism could not be established. Differential diagnosis with other entities that share some clinico-pathological and immunological features are discussed.