Eosinophils and basophils in severe fever with thrombocytopenia syndrome patients: Risk factors for predicting the prognosis on admission

Abstract

Background Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne phlebovirus with a high fatality rate. Previous studies have demonstrated the poor prognostic role of eosinophils (EOS) and basophils (BAS) in predicting multiple viral infections. This study aimed to explore the role of EOS and BAS in predicting prognosis of patients with SFTS. Methodology A total of 194 patients with SFTS who were admitted to Yantai City Hospital from November 2019 to November 2021 were included. Patients’ demographic and clinical data were collected. According to the clinical prognosis, they were divided into survival and non-survival groups. Independent risk factors were determined by univariate and multivariate logistic regression analyses. Findings There were 171 (88.14%) patients in the survived group and 23 (11.86%) patients in the non-survived group. Patients’ mean age was 62.39 ± 11.85 years old, and the proportion of males was 52.1%. Older age, neurological manifestations, hemorrhage, chemosis, and increased levels of laboratory variables, such as EOS% and BAS% on admission, were found in the non-survival group compared with the survival group. EOS%, BAS%, aspartate aminotransferase (AST), direct bilirubin (DBIL), and older age on admission were noted as independent risk factors for poor prognosis of SFTS patients. The combination of the EOS% and BAS% had an area under the curve (AUC) of (0.82; 95% CI: 0.725, 0.932, P = 0.000), which showed an excellent performance in predicting prognosis of patients with SFTS compared with neutrophil-to-lymphocyte ratio (NLR), and both exhibited a satisfactory performance in predicting poor prognosis compared with De-Ritis ratio (AST/alanine aminotransferase (ALT) ratio). EOS% and BAS% were positively correlated with various biomarkers of tissue damage and the incidence of neurological complications in SFTS patients. Conclusion EOS% and BAS% are effective predictors of poor prognosis of patients with early-stage SFTS. The combination of EOS% and BAS% was found as the most effective approach.

Clinical value of coagulation parameters in predicting the severity of severe fever with thrombocytopenia syndrome

“…Advanced age is associated with lower tolerance and a worse prognosis in SFTS patients, thus contributing to higher mortality rates. This conclusion is consistent with the findings of Liu et al (2022) .…”

MCP-3 as a prognostic biomarker for severe fever with thrombocytopenia syndrome: a longitudinal cytokine profile study

“…Other studies have demonstrated that monocytes, one of the primary target cells of SFTSV, are closely associated with severe disease in patients ( 24 ). Additionally, eosinophils, one of the central chemotactic cells of MCP-3, have been identified as an independent risk factor for adverse outcomes in patients with SFTS ( 25 ). Similarly, research has shown increased intrathecal expression of CCL7 in patients with tick-borne encephalitis ( 26 ).…”