2021
DOI: 10.1007/s00281-021-00870-z
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Eosinophils and helminth infection: protective or pathogenic?

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Cited by 36 publications
(26 citation statements)
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“…Although the infiltrate is composed of macrophages, eosinophils, scattered plasma cells, and lymphoblasts, the proportion of each cellular population is controversial. In immunocompetent hosts, eosinophils are prominent, but in their absence, the muscle larvae die [6,[15][16][17][18]. Thus, eosinophils seem to act as immunomodulators to avoid the Th1 response, which is harmful to muscular larvae survival.…”
Section: Discussionmentioning
confidence: 99%
“…Although the infiltrate is composed of macrophages, eosinophils, scattered plasma cells, and lymphoblasts, the proportion of each cellular population is controversial. In immunocompetent hosts, eosinophils are prominent, but in their absence, the muscle larvae die [6,[15][16][17][18]. Thus, eosinophils seem to act as immunomodulators to avoid the Th1 response, which is harmful to muscular larvae survival.…”
Section: Discussionmentioning
confidence: 99%
“…Following these findings, the next question is which species of the helminths contributed to the elevated eosinophil counts in the continental ancestry. Previous studies with murine models including eosinophil-free transgenic mice have indicated that the impact of eosinophils on helminth infection is not uniform; there were both evidence for eosinophil-mediated clearance of worms and increase in worm numbers 54 . Mitre and Klion mentioned, “This is due to a number of factors, including the heterogeneity of the many helminths included in the designation “helminth,” the complexity and redundancy in the host immune response to helminths, and the pleiotropic functions of eosinophils themselves” 54 .…”
Section: Discussionmentioning
confidence: 98%
“…Previous studies with murine models including eosinophil-free transgenic mice have indicated that the impact of eosinophils on helminth infection is not uniform; there were both evidence for eosinophil-mediated clearance of worms and increase in worm numbers 54 . Mitre and Klion mentioned, “This is due to a number of factors, including the heterogeneity of the many helminths included in the designation “helminth,” the complexity and redundancy in the host immune response to helminths, and the pleiotropic functions of eosinophils themselves” 54 . In future, we expect to be clarified above question by helminth eggs and helminth-derived DNA in coprolites at archaeological sites in continental East Asia and the Japanese archipelago.…”
Section: Discussionmentioning
confidence: 98%
“…The response to chronic filarial infections, while known to involve Th2 cells, is a complex interplay of innate and adaptive immune features. Among the innate granulocyte populations (also known as polymorphonuclear [PMN] cells), basophils are emerging as key immune regulators during helminth infection, 11 while eosinophils are considered the key granulocyte mediating protective anti‐helminth immunity 12,13 . In contrast neutrophils, the most abundant cell type in the human blood, are usually acknowledged for their role during bacterial, viral and fungal infections.…”
Section: Introductionmentioning
confidence: 99%