Eosinophils restrict CRC metastasis by inhibiting pro-tumorigenic SPP1+macrophage differentiation
Kristina Handler,
Deeksha Raju,
Alessandra Gurtner
et al.
Abstract:Eosinophils, traditionally associated with allergic responses, have emerged as critical immune modulators in colorectal cancer (CRC). Here, we reveal that eosinophils actively shape the tumor microenvironment and influence metastatic progression. Using comprehensive transcriptomics analysis of human CRC and a murine orthotopic tumor model, we identify a conserved tumor-specific eosinophil signature and activation profile. Despite their declining presence in advanced CRC, eosinophils suppress metastatic dissemi… Show more
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