Eotaxin-2/CCL24 and eotaxin-3/CCL26 exert differential profibrogenic effects on human lung fibroblasts

Kohan, Martin; Puxeddu, Ilaria; Reich, Reuven; Levi‐Schaffer, Francesca; Berkman, Neville

doi:10.1016/j.anai.2009.11.003

Cited by 50 publications

(43 citation statements)

References 27 publications

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“…Activated eosinophils are important sources of the potent pro‐fibrotic cytokines IL‐13 and TGF‐β, which might be involved in S. mansoni ‐induced liver fibrosis. In addition to its role in eosinophil chemotaxis, CCL24 promotes human lung fibroblast proliferation and collagen synthesis . In line with this rationale are the findings of Isgrò et al suggesting that CCL5, CCL11 and CCL24 contribute to airway recruitment of fibrocytes and airway obstruction in severe asthma patients.…”

Section: Discussionmentioning

confidence: 84%

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Plasma levels of innate immune mediators are associated with liver fibrosis in low parasite burden Schistosoma mansoni‐infected individuals

et al. 2018

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In the murine model, it was demonstrated that pro-inflammatory cytokines and chemokines are essential to the formation and modulation of Schistosoma-induced granulomatous inflammation. However, the relationship of these immune mediators and disease severity is hard to be established in naturally infected individuals. The current study evaluates the association between plasma concentrations of MIF, sTNF-R1, CCL3, CCL7 and CCL24 and schistosomiasis morbidity in Schistosoma mansoni-infected patients with a low parasite burden. For this propose, 97 S. mansoni-infected individuals were subjected to abdominal ultrasound analysis and clinical examination. Among them, 88 had plasma concentration of immune mediators estimated by ELISA assay. Multivariate linear regression models were used to evaluate the relationship between the plasma concentration of immune mediators and the variables investigated. Although most individuals presented low parasite burden, over 30% of them showed signs of fibrosis defined by ultrasound measurements and 2 patients had a severe form of schistosomiasis. No association between parasite burden and the plasma levels of chemokine/cytokines or disease severity was observed. There was a positive association between plasma concentration of CCL4, sTNF-R1, CCL3 and MIF with gall bladder thickness and/or with portal vein thickness that are liver fibrosis markers. In contrast, no association was found between CCL7 plasma concentrations with any of the schistosomiasis morbidity parameters evaluated. The data showed that CCL24, sTNFR1, MIF and CCL3 can be detected in plasma of S. mansoni-infected individuals and their concentration would be used as prognostic makers of Schistosoma-induced liver fibrosis, even in individuals with low parasite burden.

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Section: Discussionmentioning

confidence: 84%

“…In addition to its role in eosinophil chemotaxis, CCL24 promotes human lung fibroblast proliferation and collagen synthesis. 73 In line with this rationale are the findings of Isgr o et al 74 suggesting that CCL5, CCL11 and CCL24 contribute to airway recruitment of fibrocytes and airway obstruction in severe asthma patients.…”

Section: Discussionmentioning

confidence: 86%

Plasma levels of innate immune mediators are associated with liver fibrosis in low parasite burden Schistosoma mansoni‐infected individuals

et al. 2018

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“…Fibrosis is a hallmark of cardiac senescence and is associated with stiffening of the heart and impaired function [25], although the molecular and cellular bases for the accumulation of cardiac fibrosis remain unclear [26]. Age-dependent emergence of Mrc1 + GFP lo cTMs may potentiate the heart towards fibrosis by the up-regulation of genes implicated in the accumulation of cardiac fibrosis such as Fgfr1 [27], Ltc4s [28-31], Mmp9 [32], Retnla [33, 34], and Ccl24 [35]. Accordingly, these observations support the ‘hyperfunction’ model of tissue aging, which postulates that a major mechanism of tissue aging is persistent growth signalling [36, 37].…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in tissue macrophages precede cardiac functional impairment

Pinto

Godwin

Chandran

et al. 2014

Aging

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Cardiac tissue macrophages (cTMs) are abundant in the murine heart but the extent to which the cTM phenotype changes with age is unknown. This study characterizes aging-dependent phenotypic changes in cTM subsets. Using the Cx3cr1GFP/+ mouse reporter line where GFP marks cTMs, and the tissue macrophage marker Mrc1, we show that two major cardiac tissue macrophage subsets, Mrc1−GFPhi and Mrc1+GFPhi cTMs, are present in the young (<10 week old) mouse heart, and a third subset, Mrc1+GFPlo, comprises ~50% of total Mrc1+ cTMs from 30 weeks of age. Immunostaining and functional assays show that Mrc1+ cTMs are the principal myeloid sentinels in the mouse heart and that they retain proliferative capacity throughout life. Gene expression profiles of the two Mrc1+ subsets also reveal that Mrc1+GFPlo cTMs have a decreased number of immune response genes (Cx3cr1, Lpar6, CD9, Cxcr4, Itga6 and Tgfβr1), and an increased number of fibrogenic genes (Ltc4s, Retnla, Fgfr1, Mmp9 and Ccl24), consistent with a potential role for cTMs in cardiac fibrosis. These findings identify early age-dependent gene expression changes in cTMs, with significant implications for cardiac tissue injury responses and aging-associated cardiac fibrosis.

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“…Transcriptome analysis of EoE tissue showed a distinct Th2 pattern with significantly elevated mRNA levels of eotaxin-3, IL-5, IL-5 receptor a-chain and IL-13 (23,24). In experimental models, both eotaxin and IL-5 were essential for eosinophil recruitment, accumulation and activation in the esophagus as well as for epithelial hyperplasia and remodeling (25)(26)(27)(28). Moreover, IL-13 can induce eotaxin-3 production by esophageal epithelial cells (29).…”

Section: Eoe Exhibits Features Of a Th2-predominant Inflammationmentioning

confidence: 99%

Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity

Simon

Cianferoni

Spergel

et al. 2016

Allergy

204

130

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Eosinophilic esophagitis (EoE) is a chronic disease characterized clinically by symptoms of esophageal dysfunction and histologically by eosinophil-predominant inflammation. EoE is frequently associated with concomitant atopic diseases and immunoglobulin E (IgE) sensitization to food allergens in children as well as to aeroallergens and cross-reactive plant allergen components in adults. Patients with EoE respond well to elemental and empirical food elimination diets. Recent research has, however, indicated that the pathogenesis of EoE is distinct from IgE-mediated food allergy. In this review, we discuss the individual roles of epithelial barrier defects, dysregulated innate and adaptive immune responses, and of microbiota in the pathogenesis of EoE. Although food has been recognized as a trigger factor of EoE, the mechanism by which it initiates or facilitates eosinophilic inflammation appears to be largely independent of IgE and needs to be further investigated. Understanding the pathogenic role of food in EoE is a prerequisite for the development of specific diagnostic tools and targeted therapeutic procedures.Abbreviations ACD, allergic contact dermatitis; AD, atopic dermatitis; APT, atopy patch test; DHR, drug hypersensitivity reactions; EoE, eosinophilic esophagitis; FPIES, food protein-induced enterocolitis; GERD, gastroesophageal reflux disease; GI, gastrointestinal; IBD, inflammatory bowel disease; Ig, immunoglobulin; OAS, oral allergy syndrome; PPI-REE, proton pump inhibitor-responsive esophageal eosinophilia; SFED, six-food elimination diet; SPT, skin prick test; TCR, T-cell receptor; TNF, tumor necrosis factor.Allergy 71 (2016) 611-620

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Eotaxin-2/CCL24 and eotaxin-3/CCL26 exert differential profibrogenic effects on human lung fibroblasts

Cited by 50 publications

References 27 publications

Plasma levels of innate immune mediators are associated with liver fibrosis in low parasite burden Schistosoma mansoni‐infected individuals

Plasma levels of innate immune mediators are associated with liver fibrosis in low parasite burden Schistosoma mansoni‐infected individuals

Age-related changes in tissue macrophages precede cardiac functional impairment

Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity

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