Cancer rehabilitation involves helping an individual with cancer to regain maximum psychological, physical, cognitive, social, and vocational functioning with the limits up to disease and its treatments in an interdisciplinary team concept. Prostate cancer is one of the most frequent male malignancies in the world. Prostate cancer treatment options have the risk of some side effects including loss of muscle strength, fatigue, pain, urinary incontinence, erectile dysfunction, cognitive problems, decrease in bone density, weight loss, gynecomastia, and hot flushes with stress-related psychosocial problems. Relative to other cancers, the prognosis of men with prostate cancer is much better and the potential treatment-related side effects have important implications which can affect the health-related quality of life (QOL) of this population. Recent studies support the efficiency of multimodal treatment to recognize, prevent, and increase functional recovery with an interdisciplinary rehabilitation team which includes physical and occupational therapists. This chapter describes briefly cancer rehabilitation and rehabilitation approaches at every stage of patients with prostate cancer for minimizing the morbidity rate associated with prostate cancer treatment to increase occupational participation and improve QOL.