EP001/#442 The effect of mild hyperthermia on immune evasion actors PD-L1 and NLRC5 in ovarian cancer

Abstract

ResultsOut of 190 patients, 80 underwent CRS HIPEC in upfront setting and 110 in interval setting. Median age was 54±7.45 years, upfront group had higher PCI (14.1±8.75 VS. 9.6±5.2. 2), and required longer duration of surgery (10.6±1.73 vs. 8.4±1.71 hrs) had more blood loss (1025 ±668.76 vs.680±302.23 ml). Upfront group required more diaphragmatic resections, bowel resections and multivisceral resections. The overall G3-G4 morbidity was comparable (25.4%vs. 27.3%), upfront group had more surgical morbidity (20%vs.9.1%) whereas interval group had more medical morbidity i.e. electrolyte imbalance and haematological. After a median follow up of 43 months, median DFS was 33 months in upfront vs. 30 months in interval group, p=0.75, median OS was 46 months interval group and was not yet achieved in upfront group.(p=0.13). 4 year OS was 85%vs 60%. Performance status (P =0.025 C.I 1.190-12.80) was the only factor predicting morbidity on multivariate analysis. Conclusions In patients of advanced EOC upfront CRS HIPEC showed promising outcomes and better survival with similar morbidity and mortality. Upfront group had more surgical morbidity whereas interval group had more medical morbidity. Multi-institutional randomised studies are needed to define patient selection and study morbidity patterns.