EP31.08: First trimester detection of micrognathia in mid‐sagittal profile view: subjective versus objective assessment

Abstract

Objectives:To study the incidence of associated anomalies and assess the possibility of spontaneous resolution according to the longitudinal bladder diameter (LBD) in fetuses with megacystis. Methods: This is a retrospective study of prospectively collected data in fetuses diagnosed to have megacystis in the first trimester in a tertiary referral centre in South India. 84 fetuses with megacystis were assessed for presence of associated anomalies, rate of spontaneous resolution and immediate postnatal outcome during the study period from January 2007 till December 2021. All scans were performed by FMF certified operators and data was maintained on Astraia database software. Results: Of the 84 fetuses, 15 (17.8%) fetuses were part of a multiple pregnancy. 34 (40.5%) had a longitudinal bladder diameter (LBD) between 7-15 mm (G1) and 50 (59.5%) had an LBD of equal or more than 16 mm (G2). 2/34 (5.9%) and 3/50 (6%) in G1 and G2 respectively had an aneuploidy and hence terminated. 13/34 (38.2%) and 14/50 (28%) in G1 and G2 respectively had associated anomalies, mainly affecting the skeletal system and cardia. Of the 11 continuing pregnancies, 8 (72.8%) and none in G1 and G2 respectively showed spontaneous resolution before 20 weeks. Conclusions: Megacystis is an easily identifiable anomaly in the first trimester. There is nearly 6% incidence of aneuploidies, irrespective of the LBD. In our study, the incidence of spontaneous resolution in the 7-15 mm group was over 70%. However, none in the more than 16 mm group resolved spontaneously. All fetuses with diagnosis of 1st trimester megacystis must be categorised according to the LBD and offered karyotyping. In the isolated group, when LBD is less than 15 mm, the prognosis appears to be favourable in most fetuses. EP31.06Prenatal diagnosis and outcome of antenatally detected congenital talipes equinovarus deformity: a single centre study from South India