EP334/#194 Single cell transcriptomic analysis of a low grade serous ovarian cancer patient treated with pressurized intraperitoneal aerosolized chemotherapy (PIPAC)

Abstract

Results 2817 articles were screened for eligibility, of which 100 studies were submitted to full-text review. A total of 10 studies were included reporting on chemotherapy and 13 studies reporting on anti-hormonal therapy. The response rates of the 56 chemotherapy regimens that could be evaluated resulted in an ORR of 30% and a DCR of 58%. For antihormonal therapy, the results of 73 regimens led to an ORR of 11% and a DCR of 66%. Conclusions For both chemotherapy and anti-hormonal therapy, the ORR is limited, but the response rate is considerably higher when patients achieving SD are included. Additional studies are needed to provide more evidence and to standardize systemic treatment in aGCT. A Dutch prospective cohort study is ongoing.